Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

Purpose The serine-threonine kinases Aurora A (AURKA) and p21-activated kinase 1 (PAK1) are frequently overexpressed in breast tumors, with overexpression promoting aggressive breast cancer phenotypes and poor clinical outcomes. Besides the well-defined roles of these proteins in control of cell div...

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Veröffentlicht in:	Breast cancer research and treatment 2019-09, Vol.177 (2), p.369-382
Hauptverfasser:	Korobeynikov, Vladislav, Borakove, Michelle, Feng, Yayi, Wuest, William M., Koval, Alex B., Nikonova, Anna S., Serebriiskii, Ilya, Chernoff, Jonathan, Borges, Virginia F., Golemis, Erica A., Shagisultanova, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Aurora Kinase A - antagonists & inhibitors Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Care and treatment Cell cycle Cell Cycle - drug effects Cell division Cell Line, Tumor Cell survival Cell Survival - drug effects Disease Models, Animal Drug therapy Drug Therapy, Combination ErbB-2 protein Estrogen Estrogen Receptor alpha - metabolism Female Flow cytometry Humans Immunohistochemistry Kinases MAP kinase Medicine Medicine & Public Health Mice Oncology p21-activated kinase p21-Activated Kinases - antagonists & inhibitors Phenotypes Preclinical Study Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Proto-Oncogene Proteins c-myc - metabolism Serine Signal Transduction - drug effects Threonine Tumor cell lines Tumors Xenograft Model Antitumor Assays Xenografts
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