Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture

Pancreatic cancer, composed of heterogeneous cancer cells, alters epithelial to mesenchymal features during growth and metastasis. In this study, we aimed to characterize pancreatic ductal adenocarcinoma (PDAC) cells showing epithelial or mesenchymal features in 3D culture. In 3D culture, PK-1 cells...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10871-10, Article 10871
Hauptverfasser:	Shichi, Yuuki, Sasaki, Norihiko, Michishita, Masaki, Hasegawa, Fumio, Matsuda, Yoko, Arai, Tomio, Gomi, Fujiya, Aida, Junko, Takubo, Kaiyo, Toyoda, Masashi, Yoshimura, Hisashi, Takahashi, Kimimasa, Ishiwata, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 45/77 692/4028/67/1504/1713 692/4028/67/327 82/1 82/51 96/100 96/106 Adenocarcinoma Adherens junctions Antigens, Tumor-Associated, Carbohydrate - metabolism Cadherins - metabolism Carcinoma, Pancreatic Ductal - pathology Cell culture Cell Culture Techniques Cell Line, Tumor Cell Movement Cell Shape Cell Transformation, Neoplastic Cytokeratin Desmosomes Desmosomes - metabolism E-cadherin Epithelial Cells - pathology Epithelial-Mesenchymal Transition Functional morphology Gene Expression Regulation, Neoplastic Granule cells Heterogeneity Humanities and Social Sciences Humans Keratin-7 - metabolism Mesenchyme Metastases multidisciplinary Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phenotypes Science Science (multidisciplinary) Signal Transduction Smad2 protein Smad4 protein Transforming growth factor Transforming Growth Factor beta - metabolism Trypsin Vimentin Vimentin - metabolism
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