Development of latent Interferon alpha 2b as a safe therapeutic for treatment of Hepatitis C virus infection

Interferon therapy for the treatment of hepatitis C virus infection has very limited clinical application due to short serum half-life and side effects of therapy in systemic route of administration. In the present study, we have focused to improve the interferon therapy by overcoming the limitation...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10867-12, Article 10867
Hauptverfasser:	Gull, Iram, Aslam, Muhammad Shahbaz, Tipu, Imran, Mushtaq, Roohi, Ali, Tehseen Zamir, Athar, Muhammad Amin
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 38 38/77 631/61/17/1511 631/61/338/469 82 82/80 Antiviral agents Antiviral Agents - pharmacology Biological activity Cell fusion Cell Line, Tumor Cell Survival - drug effects Cytopathogenic Effect, Viral - drug effects Drug Design Female Fusion protein Hepacivirus - enzymology Hepatitis Hepatitis C Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - virology Humanities and Social Sciences Humans Infections Interferon Interferon alpha-2 - genetics Interferon alpha-2 - pharmacology Latency Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - virology Male multidisciplinary Patients Peptides - genetics Peripheral blood mononuclear cells Pichia - genetics Pichia - metabolism Plasmids - genetics Protein Precursors - genetics Proteins Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Science Science (multidisciplinary) Side effects Transforming Growth Factor beta - genetics Viral Load - drug effects Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism α-Interferon
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