Alternatively activated macrophage-derived secretome stimulates ovarian cancer spheroid spreading through a JAK2/STAT3 pathway

High-grade serous ovarian cancer (HGSOC) metastasizes when tumor spheroids detach from the primary tumor and re-attach throughout the peritoneal cavity. Once the cancer cells have implanted in these new sites, the development of metastatic lesions is dependent on the disaggregation of cancer cells f...

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Veröffentlicht in:	Cancer letters 2019-08, Vol.458, p.92-101
Hauptverfasser:	Fogg, Kaitlin C., Olson, Will R., Miller, Jamison N., Khan, Aisha, Renner, Carine, Hale, Isaac, Weisman, Paul S., Kreeger, Pamela K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Ascites Cell culture Cell Line, Tumor Collagen Cystadenocarcinoma, Serous - immunology Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - pathology Disaggregation Epidermal growth factor receptors Extracellular matrix Female FLT3L protein fms-Like Tyrosine Kinase 3 - immunology fms-Like Tyrosine Kinase 3 - metabolism Gelatinase B Heterogeneity Humans Invasiveness Janus kinase 2 Janus Kinase 2 - immunology Janus Kinase 2 - metabolism Leptin Lesions Macrophage Activation Macrophages Macrophages - immunology Macrophages - pathology Matrix Metalloproteinase 9 - immunology Matrix Metalloproteinase 9 - metabolism Medical research Metastases Metastasis Middle Aged MMP-9 Neoplasm Metastasis Ovarian cancer Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Penicillin Peritoneum Receptors, Leptin - immunology Receptors, Leptin - metabolism Secretome Signal Transduction Software Spheroids Spheroids, Cellular Spreading STAT3 Stat3 protein STAT3 Transcription Factor - immunology STAT3 Transcription Factor - metabolism Therapeutic applications Tumor microenvironment Tumors Up-Regulation Young Adult
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