In Vitro Study of Stepwise Acquisition of rv0678 and atpE Mutations Conferring Bedaquiline Resistance

Bedaquiline resistance within may arise through efflux-based ( ) or target-based ( ) pathway mutations. mutant populations from each of five sequential steps in a passaging approach, using a pyrazinamide-resistant ATCC strain, were subjected to MIC determinations and whole-genome sequencing. Exposur...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-08, Vol.63 (8)
Hauptverfasser:	Ismail, Nabila, Ismail, Nazir A, Omar, Shaheed V, Peters, Remco P H
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins Diarylquinolines Drug Resistance, Bacterial Mechanisms of Resistance Mutation Mycobacterium tuberculosis
Online-Zugang:	Volltext
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