Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ

NOTCH plays a pivotal role during normal development and in congenital disorders and cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block processing of numerous other proteins. We discovered a new class of small molecule inhibitor that disrupts the interaction bet...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10811-9, Article 10811
Hauptverfasser:	Hurtado, Cecilia, Safarova, Alena, Smith, Michael, Chung, Raeeun, Bruyneel, Arne A. N., Gomez-Galeno, Jorge, Oswald, Franz, Larson, Christopher J., Cashman, John R., Ruiz-Lozano, Pilar, Janiak, Philip, Suzuki, Teri, Mercola, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 631/154 631/92/507 Cell differentiation Cell Differentiation - drug effects Cell Line Gene expression Gene Expression Regulation - drug effects Humanities and Social Sciences Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein - antagonists & inhibitors Kinases multidisciplinary Myoblasts Myoblasts - drug effects Myoblasts - metabolism Receptors, Notch - metabolism Science Science (multidisciplinary) Secretase Signal Transduction - drug effects siRNA Skeletal muscle Therapeutic applications Tumor cell lines
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