Pulmonary hypertension: Newer concepts in diagnosis and management
Pulmonary hypertension comprises a family of disorders occurring as a primary disease or as a complication of a large number of respiratory and cardiac diseases. Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the...
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| Veröffentlicht in: | Clinical cardiology (Mahwah, N.J.) N.J.), 1997-08, Vol.20 (8), p.676-682 |
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| container_title | Clinical cardiology (Mahwah, N.J.) |
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| creator | Moraes, Denzil Loscalzo, Joseph |
| description | Pulmonary hypertension comprises a family of disorders occurring as a primary disease or as a complication of a large number of respiratory and cardiac diseases. Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the hemodynamic changes that result in pulmonary hypertension, whether from hypoxia, acidosis, increased pulmonary blood flow, increased shear stress, or idiopathic causes, is a dysfunctional vascular endothelium. In this review, the role of the history and physical examination in the initial assessment is emphasized. Newer diagnostic modalities, such as subselective pulmonary angiography and ultrafast computed tomography scanning, are reviewed. Low‐flow oxygen, anticoagulation, and calcium‐channel blockade are presented as accepted therapeutic modalities. Inhaled nitric oxide and prostacyclin infusion are presented as newer therapies that may be useful given the limited availability of donor organs for heart‐lung transplantation. Future therapeutic strategies are likely to develop from advances in vascular biology. |
| doi_str_mv | 10.1002/clc.4960200804 |
| format | Article |
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Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the hemodynamic changes that result in pulmonary hypertension, whether from hypoxia, acidosis, increased pulmonary blood flow, increased shear stress, or idiopathic causes, is a dysfunctional vascular endothelium. In this review, the role of the history and physical examination in the initial assessment is emphasized. Newer diagnostic modalities, such as subselective pulmonary angiography and ultrafast computed tomography scanning, are reviewed. Low‐flow oxygen, anticoagulation, and calcium‐channel blockade are presented as accepted therapeutic modalities. Inhaled nitric oxide and prostacyclin infusion are presented as newer therapies that may be useful given the limited availability of donor organs for heart‐lung transplantation. Future therapeutic strategies are likely to develop from advances in vascular biology.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.4960200804</identifier><identifier>PMID: 9259160</identifier><identifier>CODEN: CLCADC</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>anticoagulation ; Biological and medical sciences ; Blood Viscosity ; endothelial cell ; Endothelium, Vascular ; Humans ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - physiopathology ; Hypertension, Pulmonary - therapy ; Medical sciences ; nitric oxide ; Pneumology ; Pulmonary Circulation ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Pulmonary Wedge Pressure ; Review</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 1997-08, Vol.20 (8), p.676-682</ispartof><rights>Copyright © 1997 Wiley Periodicals, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4644-6f1cd1a6f501f7d38177ff242870573079313caddcaad5bda52c93dc5380ea113</citedby><cites>FETCH-LOGICAL-c4644-6f1cd1a6f501f7d38177ff242870573079313caddcaad5bda52c93dc5380ea113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655772/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655772/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27903,27904,45553,45554,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2764744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9259160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moraes, Denzil</creatorcontrib><creatorcontrib>Loscalzo, Joseph</creatorcontrib><title>Pulmonary hypertension: Newer concepts in diagnosis and management</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Pulmonary hypertension comprises a family of disorders occurring as a primary disease or as a complication of a large number of respiratory and cardiac diseases. Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the hemodynamic changes that result in pulmonary hypertension, whether from hypoxia, acidosis, increased pulmonary blood flow, increased shear stress, or idiopathic causes, is a dysfunctional vascular endothelium. In this review, the role of the history and physical examination in the initial assessment is emphasized. Newer diagnostic modalities, such as subselective pulmonary angiography and ultrafast computed tomography scanning, are reviewed. Low‐flow oxygen, anticoagulation, and calcium‐channel blockade are presented as accepted therapeutic modalities. Inhaled nitric oxide and prostacyclin infusion are presented as newer therapies that may be useful given the limited availability of donor organs for heart‐lung transplantation. Future therapeutic strategies are likely to develop from advances in vascular biology.</description><subject>anticoagulation</subject><subject>Biological and medical sciences</subject><subject>Blood Viscosity</subject><subject>endothelial cell</subject><subject>Endothelium, Vascular</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Hypertension, Pulmonary - therapy</subject><subject>Medical sciences</subject><subject>nitric oxide</subject><subject>Pneumology</subject><subject>Pulmonary Circulation</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Pulmonary Wedge Pressure</subject><subject>Review</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EKuWxsiFlQGwpfiRxzIAEFS-pAgaYrVvbKUaJXeyWqv8eV60KTEx3OOeec_QhdELwgGBML1SrBoWoMMW4xsUO6hPBaF5zxndRH5MK54LWYh8dxPiR_LimrId6gpYiaX108zJvO-8gLLP35dSEmXHReneZPZmFCZnyTpnpLGbWZdrCxPloYwZOZx04mJjOuNkR2mugjeZ4cw_R293t6_AhHz3fPw6vR7kqqqLIq4YoTaBqSkwarllNOG8aWtCa45IzzAUjTIHWCkCXYw0lVYJpVbIaGyCEHaKrde50Pu6MVqk6QCunwXZpvvRg5V_F2Xc58V-yqsqSc5oCzjcBwX_OTZzJzkZl2hac8fMouUh4iFg1DdZGFXyMwTTbEoLlirpM1OUP9fRw-nva1r7BnPSzjQ5RQdsEcMrGrY3yquDFKkasbQvbmuU_pXI4Gv6a8A29dpw0</recordid><startdate>199708</startdate><enddate>199708</enddate><creator>Moraes, Denzil</creator><creator>Loscalzo, Joseph</creator><general>Wiley Periodicals, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199708</creationdate><title>Pulmonary hypertension: Newer concepts in diagnosis and management</title><author>Moraes, Denzil ; Loscalzo, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4644-6f1cd1a6f501f7d38177ff242870573079313caddcaad5bda52c93dc5380ea113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>anticoagulation</topic><topic>Biological and medical sciences</topic><topic>Blood Viscosity</topic><topic>endothelial cell</topic><topic>Endothelium, Vascular</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Hypertension, Pulmonary - therapy</topic><topic>Medical sciences</topic><topic>nitric oxide</topic><topic>Pneumology</topic><topic>Pulmonary Circulation</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Pulmonary Wedge Pressure</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moraes, Denzil</creatorcontrib><creatorcontrib>Loscalzo, Joseph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moraes, Denzil</au><au>Loscalzo, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary hypertension: Newer concepts in diagnosis and management</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>1997-08</date><risdate>1997</risdate><volume>20</volume><issue>8</issue><spage>676</spage><epage>682</epage><pages>676-682</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><coden>CLCADC</coden><abstract>Pulmonary hypertension comprises a family of disorders occurring as a primary disease or as a complication of a large number of respiratory and cardiac diseases. Pulmonary hypertension is present when pulmonary artery pressure or mean pressure exceeds 30 mmHg or 20 mmHg, respectively. Underlying the hemodynamic changes that result in pulmonary hypertension, whether from hypoxia, acidosis, increased pulmonary blood flow, increased shear stress, or idiopathic causes, is a dysfunctional vascular endothelium. In this review, the role of the history and physical examination in the initial assessment is emphasized. Newer diagnostic modalities, such as subselective pulmonary angiography and ultrafast computed tomography scanning, are reviewed. Low‐flow oxygen, anticoagulation, and calcium‐channel blockade are presented as accepted therapeutic modalities. Inhaled nitric oxide and prostacyclin infusion are presented as newer therapies that may be useful given the limited availability of donor organs for heart‐lung transplantation. Future therapeutic strategies are likely to develop from advances in vascular biology.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>9259160</pmid><doi>10.1002/clc.4960200804</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0160-9289 |
| ispartof | Clinical cardiology (Mahwah, N.J.), 1997-08, Vol.20 (8), p.676-682 |
| issn | 0160-9289 1932-8737 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | anticoagulation Biological and medical sciences Blood Viscosity endothelial cell Endothelium, Vascular Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - therapy Medical sciences nitric oxide Pneumology Pulmonary Circulation Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Pulmonary Wedge Pressure Review |
| title | Pulmonary hypertension: Newer concepts in diagnosis and management |
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