Shear‐induced platelet aggregation increases in patients with proximal and severe coronary artery stenosis
Background: Shear stress generated in stenosed arteries promotes platelet thrombi formation at the stenosed sites by accelerating the binding of von Willebrand factor (vWF) to platelets. Shear‐induced platelet aggregation (SIPA) has been studied in acute coronary syndromes, but not in chronic corona...
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| Veröffentlicht in: | Clinical cardiology (Mahwah, N.J.) N.J.), 2002-04, Vol.25 (4), p.154-160 |
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| creator | Kawano, Koichi Yoshino, Hideaki Aoki, Nobuo Udagawa, Hiroshi Watanuki, Atsushi Hioki, Yoshiko Hasumura, Yukihisa Yasumura, Toshikaki Homori, Masashi Murata, Mitsuru Ikeda, Yasuo Ishikawa, Kyozo |
| description | Background: Shear stress generated in stenosed arteries promotes platelet thrombi formation at the stenosed sites by accelerating the binding of von Willebrand factor (vWF) to platelets. Shear‐induced platelet aggregation (SIPA) has been studied in acute coronary syndromes, but not in chronic coronary disease.
Hypothesis: We investigated the effect of both the site and severity of coronary stenosis on SIPAin patients with chronic coronary artery disease.
Methods: Shear‐induced platelet aggregation was measured using platelet‐rich plasma in 49 patients (41 men and 8 women; mean age 61 ± 10 years) with coronary artery disease to evaluate the association between the extent of SIPA and coronary angiographic findings. Stenoses > 75% were considered severe. In all, 62 healthy individuals (54 men and 18 women; mean age 45 ± 7 years) served as controls. The correlation between SIPA and the site and severity of the coronary lesion, and parameters of coagulation and fibrinolysis were evaluated.
Results: Shear‐induced platelet aggregation was increased in the stenosis group (69.0 ± 10.6%) compared with the controls (57.7 ± 10.3%, p < 0.0001). Patients with severe stenosis in the proximal segments had significantly increased SIPA (p< 0.0001) and vWF larger multimer concentration (p < 0.0001) compared with the control group. A significant correlation existed between SIPA and the vWF larger multimer concentrationinall subjects studied (r= 0.422, p |
| doi_str_mv | 10.1002/clc.4960250405 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6654518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71661127</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4665-db4c9120b05f39c286ded453a18d2572bd9bf4f2fe1ae1df4b9670cdbb49a76c3</originalsourceid><addsrcrecordid>eNqFkU-vEyEUxYnR-OrTrUvDRndTgWGYYWNiGv8lTVyoa3IH7rQYChWm79mdH8HP6CcR08Y-V7K55PLjnJMcQp5ytuSMiZc22KXUiomOSdbdIwuuW9EMfdvfJwvGFWu0GPQVeVTK18qzQbQPyRUXrJ5eLEj4tEXIv3789NEdLDq6DzBjwJnCZpNxA7NPkfpoM0LBUm90X3cY50Jv_byl-5y--x0ECtHRgjeYkdqUU4R8pJBnrKPMGFPx5TF5MEEo-OQ8r8mXt28-r94364_vPqxerxsrleoaN0qra8SRdVOrrRiUQye7FvjgRNeL0elxkpOYkANyN8lRq55ZN45SQ69se01enXT3h3GHzta0GYLZ5xo0H00Cb_59iX5rNunGVHfZ8aEKvDgL5PTtgGU2O18shgAR06GYnivFuegruDyBNqdSMk5_TTgzfwoytSBzKah-eHY32gU_N1KB52cAioUwZYjWlwvXdr1iSlZOn7hbH_D4H1uzWq_uhPgNySGuyA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71661127</pqid></control><display><type>article</type><title>Shear‐induced platelet aggregation increases in patients with proximal and severe coronary artery stenosis</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Kawano, Koichi ; Yoshino, Hideaki ; Aoki, Nobuo ; Udagawa, Hiroshi ; Watanuki, Atsushi ; Hioki, Yoshiko ; Hasumura, Yukihisa ; Yasumura, Toshikaki ; Homori, Masashi ; Murata, Mitsuru ; Ikeda, Yasuo ; Ishikawa, Kyozo</creator><creatorcontrib>Kawano, Koichi ; Yoshino, Hideaki ; Aoki, Nobuo ; Udagawa, Hiroshi ; Watanuki, Atsushi ; Hioki, Yoshiko ; Hasumura, Yukihisa ; Yasumura, Toshikaki ; Homori, Masashi ; Murata, Mitsuru ; Ikeda, Yasuo ; Ishikawa, Kyozo</creatorcontrib><description>Background: Shear stress generated in stenosed arteries promotes platelet thrombi formation at the stenosed sites by accelerating the binding of von Willebrand factor (vWF) to platelets. Shear‐induced platelet aggregation (SIPA) has been studied in acute coronary syndromes, but not in chronic coronary disease.
Hypothesis: We investigated the effect of both the site and severity of coronary stenosis on SIPAin patients with chronic coronary artery disease.
Methods: Shear‐induced platelet aggregation was measured using platelet‐rich plasma in 49 patients (41 men and 8 women; mean age 61 ± 10 years) with coronary artery disease to evaluate the association between the extent of SIPA and coronary angiographic findings. Stenoses > 75% were considered severe. In all, 62 healthy individuals (54 men and 18 women; mean age 45 ± 7 years) served as controls. The correlation between SIPA and the site and severity of the coronary lesion, and parameters of coagulation and fibrinolysis were evaluated.
Results: Shear‐induced platelet aggregation was increased in the stenosis group (69.0 ± 10.6%) compared with the controls (57.7 ± 10.3%, p < 0.0001). Patients with severe stenosis in the proximal segments had significantly increased SIPA (p< 0.0001) and vWF larger multimer concentration (p < 0.0001) compared with the control group. A significant correlation existed between SIPA and the vWF larger multimer concentrationinall subjects studied (r= 0.422, p<0.0001).
Conclusions: Shear‐induced platelet aggregation is increased in patients with severe stenosis of the proximal coronary arteries and correlates with plasma concentrations of vWF larger multimers, suggesting that severe stenosis in the proximal segments is not only associated with an increased risk of significant my ocardial ischemia, but may also generate high shear stress in the stenosed artery and increase plasma vWF larger multimers, thereby promoting the formation of platelet thrombi.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.4960250405</identifier><identifier>PMID: 12000072</identifier><identifier>CODEN: CLCADC</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Angina Pectoris - blood ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Clinical Investigation ; Clinical Investigations ; Coronary Angiography ; coronary disease ; Coronary heart disease ; Coronary Stenosis - blood ; Coronary Stenosis - pathology ; Female ; Heart ; Hemorheology ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; platelet ; Platelet Aggregation - physiology ; stenosis ; Thrombosis - etiology ; von Willebrand factor ; von Willebrand Factor - analysis</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2002-04, Vol.25 (4), p.154-160</ispartof><rights>Copyright © 2002 Wiley Periodicals, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4665-db4c9120b05f39c286ded453a18d2572bd9bf4f2fe1ae1df4b9670cdbb49a76c3</citedby><cites>FETCH-LOGICAL-c4665-db4c9120b05f39c286ded453a18d2572bd9bf4f2fe1ae1df4b9670cdbb49a76c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6654518/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6654518/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27903,27904,45553,45554,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13576064$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12000072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawano, Koichi</creatorcontrib><creatorcontrib>Yoshino, Hideaki</creatorcontrib><creatorcontrib>Aoki, Nobuo</creatorcontrib><creatorcontrib>Udagawa, Hiroshi</creatorcontrib><creatorcontrib>Watanuki, Atsushi</creatorcontrib><creatorcontrib>Hioki, Yoshiko</creatorcontrib><creatorcontrib>Hasumura, Yukihisa</creatorcontrib><creatorcontrib>Yasumura, Toshikaki</creatorcontrib><creatorcontrib>Homori, Masashi</creatorcontrib><creatorcontrib>Murata, Mitsuru</creatorcontrib><creatorcontrib>Ikeda, Yasuo</creatorcontrib><creatorcontrib>Ishikawa, Kyozo</creatorcontrib><title>Shear‐induced platelet aggregation increases in patients with proximal and severe coronary artery stenosis</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Background: Shear stress generated in stenosed arteries promotes platelet thrombi formation at the stenosed sites by accelerating the binding of von Willebrand factor (vWF) to platelets. Shear‐induced platelet aggregation (SIPA) has been studied in acute coronary syndromes, but not in chronic coronary disease.
Hypothesis: We investigated the effect of both the site and severity of coronary stenosis on SIPAin patients with chronic coronary artery disease.
Methods: Shear‐induced platelet aggregation was measured using platelet‐rich plasma in 49 patients (41 men and 8 women; mean age 61 ± 10 years) with coronary artery disease to evaluate the association between the extent of SIPA and coronary angiographic findings. Stenoses > 75% were considered severe. In all, 62 healthy individuals (54 men and 18 women; mean age 45 ± 7 years) served as controls. The correlation between SIPA and the site and severity of the coronary lesion, and parameters of coagulation and fibrinolysis were evaluated.
Results: Shear‐induced platelet aggregation was increased in the stenosis group (69.0 ± 10.6%) compared with the controls (57.7 ± 10.3%, p < 0.0001). Patients with severe stenosis in the proximal segments had significantly increased SIPA (p< 0.0001) and vWF larger multimer concentration (p < 0.0001) compared with the control group. A significant correlation existed between SIPA and the vWF larger multimer concentrationinall subjects studied (r= 0.422, p<0.0001).
Conclusions: Shear‐induced platelet aggregation is increased in patients with severe stenosis of the proximal coronary arteries and correlates with plasma concentrations of vWF larger multimers, suggesting that severe stenosis in the proximal segments is not only associated with an increased risk of significant my ocardial ischemia, but may also generate high shear stress in the stenosed artery and increase plasma vWF larger multimers, thereby promoting the formation of platelet thrombi.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Angina Pectoris - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Clinical Investigation</subject><subject>Clinical Investigations</subject><subject>Coronary Angiography</subject><subject>coronary disease</subject><subject>Coronary heart disease</subject><subject>Coronary Stenosis - blood</subject><subject>Coronary Stenosis - pathology</subject><subject>Female</subject><subject>Heart</subject><subject>Hemorheology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>platelet</subject><subject>Platelet Aggregation - physiology</subject><subject>stenosis</subject><subject>Thrombosis - etiology</subject><subject>von Willebrand factor</subject><subject>von Willebrand Factor - analysis</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-vEyEUxYnR-OrTrUvDRndTgWGYYWNiGv8lTVyoa3IH7rQYChWm79mdH8HP6CcR08Y-V7K55PLjnJMcQp5ytuSMiZc22KXUiomOSdbdIwuuW9EMfdvfJwvGFWu0GPQVeVTK18qzQbQPyRUXrJ5eLEj4tEXIv3789NEdLDq6DzBjwJnCZpNxA7NPkfpoM0LBUm90X3cY50Jv_byl-5y--x0ECtHRgjeYkdqUU4R8pJBnrKPMGFPx5TF5MEEo-OQ8r8mXt28-r94364_vPqxerxsrleoaN0qra8SRdVOrrRiUQye7FvjgRNeL0elxkpOYkANyN8lRq55ZN45SQ69se01enXT3h3GHzta0GYLZ5xo0H00Cb_59iX5rNunGVHfZ8aEKvDgL5PTtgGU2O18shgAR06GYnivFuegruDyBNqdSMk5_TTgzfwoytSBzKah-eHY32gU_N1KB52cAioUwZYjWlwvXdr1iSlZOn7hbH_D4H1uzWq_uhPgNySGuyA</recordid><startdate>200204</startdate><enddate>200204</enddate><creator>Kawano, Koichi</creator><creator>Yoshino, Hideaki</creator><creator>Aoki, Nobuo</creator><creator>Udagawa, Hiroshi</creator><creator>Watanuki, Atsushi</creator><creator>Hioki, Yoshiko</creator><creator>Hasumura, Yukihisa</creator><creator>Yasumura, Toshikaki</creator><creator>Homori, Masashi</creator><creator>Murata, Mitsuru</creator><creator>Ikeda, Yasuo</creator><creator>Ishikawa, Kyozo</creator><general>Wiley Periodicals, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200204</creationdate><title>Shear‐induced platelet aggregation increases in patients with proximal and severe coronary artery stenosis</title><author>Kawano, Koichi ; Yoshino, Hideaki ; Aoki, Nobuo ; Udagawa, Hiroshi ; Watanuki, Atsushi ; Hioki, Yoshiko ; Hasumura, Yukihisa ; Yasumura, Toshikaki ; Homori, Masashi ; Murata, Mitsuru ; Ikeda, Yasuo ; Ishikawa, Kyozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4665-db4c9120b05f39c286ded453a18d2572bd9bf4f2fe1ae1df4b9670cdbb49a76c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Angina Pectoris - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Clinical Investigation</topic><topic>Clinical Investigations</topic><topic>Coronary Angiography</topic><topic>coronary disease</topic><topic>Coronary heart disease</topic><topic>Coronary Stenosis - blood</topic><topic>Coronary Stenosis - pathology</topic><topic>Female</topic><topic>Heart</topic><topic>Hemorheology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>platelet</topic><topic>Platelet Aggregation - physiology</topic><topic>stenosis</topic><topic>Thrombosis - etiology</topic><topic>von Willebrand factor</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawano, Koichi</creatorcontrib><creatorcontrib>Yoshino, Hideaki</creatorcontrib><creatorcontrib>Aoki, Nobuo</creatorcontrib><creatorcontrib>Udagawa, Hiroshi</creatorcontrib><creatorcontrib>Watanuki, Atsushi</creatorcontrib><creatorcontrib>Hioki, Yoshiko</creatorcontrib><creatorcontrib>Hasumura, Yukihisa</creatorcontrib><creatorcontrib>Yasumura, Toshikaki</creatorcontrib><creatorcontrib>Homori, Masashi</creatorcontrib><creatorcontrib>Murata, Mitsuru</creatorcontrib><creatorcontrib>Ikeda, Yasuo</creatorcontrib><creatorcontrib>Ishikawa, Kyozo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawano, Koichi</au><au>Yoshino, Hideaki</au><au>Aoki, Nobuo</au><au>Udagawa, Hiroshi</au><au>Watanuki, Atsushi</au><au>Hioki, Yoshiko</au><au>Hasumura, Yukihisa</au><au>Yasumura, Toshikaki</au><au>Homori, Masashi</au><au>Murata, Mitsuru</au><au>Ikeda, Yasuo</au><au>Ishikawa, Kyozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shear‐induced platelet aggregation increases in patients with proximal and severe coronary artery stenosis</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>2002-04</date><risdate>2002</risdate><volume>25</volume><issue>4</issue><spage>154</spage><epage>160</epage><pages>154-160</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><coden>CLCADC</coden><abstract>Background: Shear stress generated in stenosed arteries promotes platelet thrombi formation at the stenosed sites by accelerating the binding of von Willebrand factor (vWF) to platelets. Shear‐induced platelet aggregation (SIPA) has been studied in acute coronary syndromes, but not in chronic coronary disease.
Hypothesis: We investigated the effect of both the site and severity of coronary stenosis on SIPAin patients with chronic coronary artery disease.
Methods: Shear‐induced platelet aggregation was measured using platelet‐rich plasma in 49 patients (41 men and 8 women; mean age 61 ± 10 years) with coronary artery disease to evaluate the association between the extent of SIPA and coronary angiographic findings. Stenoses > 75% were considered severe. In all, 62 healthy individuals (54 men and 18 women; mean age 45 ± 7 years) served as controls. The correlation between SIPA and the site and severity of the coronary lesion, and parameters of coagulation and fibrinolysis were evaluated.
Results: Shear‐induced platelet aggregation was increased in the stenosis group (69.0 ± 10.6%) compared with the controls (57.7 ± 10.3%, p < 0.0001). Patients with severe stenosis in the proximal segments had significantly increased SIPA (p< 0.0001) and vWF larger multimer concentration (p < 0.0001) compared with the control group. A significant correlation existed between SIPA and the vWF larger multimer concentrationinall subjects studied (r= 0.422, p<0.0001).
Conclusions: Shear‐induced platelet aggregation is increased in patients with severe stenosis of the proximal coronary arteries and correlates with plasma concentrations of vWF larger multimers, suggesting that severe stenosis in the proximal segments is not only associated with an increased risk of significant my ocardial ischemia, but may also generate high shear stress in the stenosed artery and increase plasma vWF larger multimers, thereby promoting the formation of platelet thrombi.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>12000072</pmid><doi>10.1002/clc.4960250405</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Analysis of Variance Angina Pectoris - blood Biological and medical sciences Cardiology. Vascular system Case-Control Studies Clinical Investigation Clinical Investigations Coronary Angiography coronary disease Coronary heart disease Coronary Stenosis - blood Coronary Stenosis - pathology Female Heart Hemorheology Humans Male Medical sciences Middle Aged Myocardial Infarction - blood platelet Platelet Aggregation - physiology stenosis Thrombosis - etiology von Willebrand factor von Willebrand Factor - analysis |
| title | Shear‐induced platelet aggregation increases in patients with proximal and severe coronary artery stenosis |
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