Myocardial bridging increases the risk of coronary spasm
Background: Myocardial bridging (MB) has been associated with cardiac events. Whether coronary spasm is one factor contributing to those events is unknown. Hypothesis: This study investigated whether the likelihood of coronary spasm is increased in patients with MB. Methods: A spasm‐provocation test...
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| Veröffentlicht in: | Clinical cardiology (Mahwah, N.J.) N.J.), 2003-08, Vol.26 (8), p.377-383 |
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| container_title | Clinical cardiology (Mahwah, N.J.) |
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| creator | Teragawa, Hiroki Fukuda, Yukihiro Matsuda, Keiji Hirao, Hidekazu Higashi, Yukihito Yamagata, Togo Oshima, Tetsuya Matsuura, Hideo Chayama, Kazuaki |
| description | Background: Myocardial bridging (MB) has been associated with cardiac events. Whether coronary spasm is one factor contributing to those events is unknown.
Hypothesis: This study investigated whether the likelihood of coronary spasm is increased in patients with MB.
Methods: A spasm‐provocation test was performed by infusing acetylcholine into the left coronary artery in 114 Japanese patients with chest pain. The test result was defined as positive when the diameter of the coronary artery was reduced by > 50% and ST‐segment changes were documented. Myocardial bridging was defined as a > 15% reduction in coronary arterial diameter during systole after intracoronary injection of nitroglycerin.
Results: Myocardial bridging was identified in 41 patients (36%) and was located in the mid‐segment of the left anterior descending coronary artery (LAD) in all patients. Patients with MB experienced coronary spasm more frequently than patients without MB (MB+: 73%; MB —: 40%, p = 0.0006). Furthermore, among patients with a positive spasm‐provocation test, coronary spasm occurred more frequently in the midsegment of the LAD in patients with MB than in those without MB (MB+: 73%; MB — : 45%, p = 0.0259). Multivariate regression analysis demonstrated that MB was a predictor of coronary spasm (odds ratio: 3.478, p = 0.0088).
Conclusions: These results suggest that MB increases the risk of coronary spasm and that coronary spasm may be the proximate etiology of cardiac events associated with MB. |
| doi_str_mv | 10.1002/clc.4950260806 |
| format | Article |
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Hypothesis: This study investigated whether the likelihood of coronary spasm is increased in patients with MB.
Methods: A spasm‐provocation test was performed by infusing acetylcholine into the left coronary artery in 114 Japanese patients with chest pain. The test result was defined as positive when the diameter of the coronary artery was reduced by > 50% and ST‐segment changes were documented. Myocardial bridging was defined as a > 15% reduction in coronary arterial diameter during systole after intracoronary injection of nitroglycerin.
Results: Myocardial bridging was identified in 41 patients (36%) and was located in the mid‐segment of the left anterior descending coronary artery (LAD) in all patients. Patients with MB experienced coronary spasm more frequently than patients without MB (MB+: 73%; MB —: 40%, p = 0.0006). Furthermore, among patients with a positive spasm‐provocation test, coronary spasm occurred more frequently in the midsegment of the LAD in patients with MB than in those without MB (MB+: 73%; MB — : 45%, p = 0.0259). Multivariate regression analysis demonstrated that MB was a predictor of coronary spasm (odds ratio: 3.478, p = 0.0088).
Conclusions: These results suggest that MB increases the risk of coronary spasm and that coronary spasm may be the proximate etiology of cardiac events associated with MB.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.4950260806</identifier><identifier>PMID: 12918640</identifier><identifier>CODEN: CLCADC</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Acetylcholine - administration & dosage ; Acetylcholine - pharmacology ; Angina Pectoris - complications ; Angina Pectoris - diagnosis ; Angina Pectoris - drug therapy ; Arteries - drug effects ; Biological and medical sciences ; cardiac sudden death ; Cardiology. Vascular system ; Clinical Investigation ; Clinical Investigations ; Coronary Angiography ; coronary artery ; Coronary heart disease ; Coronary Vasospasm - diagnosis ; Coronary Vasospasm - diagnostic imaging ; Coronary Vasospasm - etiology ; Coronary Vessels - drug effects ; Female ; Heart ; Humans ; Injections, Intra-Arterial ; Key words: vasospastic angina ; Male ; Medical sciences ; Middle Aged ; Nitroglycerin - administration & dosage ; Predictive Value of Tests ; Risk Factors ; Ultrasonography ; Vasodilator Agents - administration & dosage ; Vasodilator Agents - pharmacology</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2003-08, Vol.26 (8), p.377-383</ispartof><rights>Copyright © 2003 Wiley Periodicals, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5326-39f41b8238c0806b895115b3117fcbf066c98ed9fddeb8f846132bdb72dba6733</citedby><cites>FETCH-LOGICAL-c5326-39f41b8238c0806b895115b3117fcbf066c98ed9fddeb8f846132bdb72dba6733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653965/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653965/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15027692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12918640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teragawa, Hiroki</creatorcontrib><creatorcontrib>Fukuda, Yukihiro</creatorcontrib><creatorcontrib>Matsuda, Keiji</creatorcontrib><creatorcontrib>Hirao, Hidekazu</creatorcontrib><creatorcontrib>Higashi, Yukihito</creatorcontrib><creatorcontrib>Yamagata, Togo</creatorcontrib><creatorcontrib>Oshima, Tetsuya</creatorcontrib><creatorcontrib>Matsuura, Hideo</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><title>Myocardial bridging increases the risk of coronary spasm</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Background: Myocardial bridging (MB) has been associated with cardiac events. Whether coronary spasm is one factor contributing to those events is unknown.
Hypothesis: This study investigated whether the likelihood of coronary spasm is increased in patients with MB.
Methods: A spasm‐provocation test was performed by infusing acetylcholine into the left coronary artery in 114 Japanese patients with chest pain. The test result was defined as positive when the diameter of the coronary artery was reduced by > 50% and ST‐segment changes were documented. Myocardial bridging was defined as a > 15% reduction in coronary arterial diameter during systole after intracoronary injection of nitroglycerin.
Results: Myocardial bridging was identified in 41 patients (36%) and was located in the mid‐segment of the left anterior descending coronary artery (LAD) in all patients. Patients with MB experienced coronary spasm more frequently than patients without MB (MB+: 73%; MB —: 40%, p = 0.0006). Furthermore, among patients with a positive spasm‐provocation test, coronary spasm occurred more frequently in the midsegment of the LAD in patients with MB than in those without MB (MB+: 73%; MB — : 45%, p = 0.0259). Multivariate regression analysis demonstrated that MB was a predictor of coronary spasm (odds ratio: 3.478, p = 0.0088).
Conclusions: These results suggest that MB increases the risk of coronary spasm and that coronary spasm may be the proximate etiology of cardiac events associated with MB.</description><subject>Acetylcholine - administration & dosage</subject><subject>Acetylcholine - pharmacology</subject><subject>Angina Pectoris - complications</subject><subject>Angina Pectoris - diagnosis</subject><subject>Angina Pectoris - drug therapy</subject><subject>Arteries - drug effects</subject><subject>Biological and medical sciences</subject><subject>cardiac sudden death</subject><subject>Cardiology. Vascular system</subject><subject>Clinical Investigation</subject><subject>Clinical Investigations</subject><subject>Coronary Angiography</subject><subject>coronary artery</subject><subject>Coronary heart disease</subject><subject>Coronary Vasospasm - diagnosis</subject><subject>Coronary Vasospasm - diagnostic imaging</subject><subject>Coronary Vasospasm - etiology</subject><subject>Coronary Vessels - drug effects</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Injections, Intra-Arterial</subject><subject>Key words: vasospastic angina</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Ultrasonography</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EoqWwMqIssKX4kTj2goQiXlIRC8yW7ditIY2L3YL673HViJaJ4eoO97vnHB0AzhEcIwjxtW71uOAlxBQySA_AEHGCc1aR6hAMIaIw55jxATiJ8T3xkGFyDAYIc8RoAYeAPa-9lqFxss1UcM3UddPMdToYGU3MljOTBRc_Mm8z7YPvZFhncSHj_BQcWdlGc9bvEXi7v3utH_PJy8NTfTvJdUkwzQm3BVLJlelNQMV4iVCpCEKV1cpCSjVnpuG2aYxilhUUEawaVeFGSVoRMgI3W93FSs1No023DLIVi-DmKYvw0om_l87NxNR_CUpLwtOMwFUvEPznysSlmLuoTdvKzvhVFBUpK06KIoHjLaiDjzEY-2uCoNiULVLZYld2erjYj7bD-3YTcNkDMmrZ2iA77eKOS0oV5ThxfMt9u9as_7EV9aTeC_EDfO-YwQ</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Teragawa, Hiroki</creator><creator>Fukuda, Yukihiro</creator><creator>Matsuda, Keiji</creator><creator>Hirao, Hidekazu</creator><creator>Higashi, Yukihito</creator><creator>Yamagata, Togo</creator><creator>Oshima, Tetsuya</creator><creator>Matsuura, Hideo</creator><creator>Chayama, Kazuaki</creator><general>Wiley Periodicals, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200308</creationdate><title>Myocardial bridging increases the risk of coronary spasm</title><author>Teragawa, Hiroki ; Fukuda, Yukihiro ; Matsuda, Keiji ; Hirao, Hidekazu ; Higashi, Yukihito ; Yamagata, Togo ; Oshima, Tetsuya ; Matsuura, Hideo ; Chayama, Kazuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5326-39f41b8238c0806b895115b3117fcbf066c98ed9fddeb8f846132bdb72dba6733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acetylcholine - administration & dosage</topic><topic>Acetylcholine - pharmacology</topic><topic>Angina Pectoris - complications</topic><topic>Angina Pectoris - diagnosis</topic><topic>Angina Pectoris - drug therapy</topic><topic>Arteries - drug effects</topic><topic>Biological and medical sciences</topic><topic>cardiac sudden death</topic><topic>Cardiology. Vascular system</topic><topic>Clinical Investigation</topic><topic>Clinical Investigations</topic><topic>Coronary Angiography</topic><topic>coronary artery</topic><topic>Coronary heart disease</topic><topic>Coronary Vasospasm - diagnosis</topic><topic>Coronary Vasospasm - diagnostic imaging</topic><topic>Coronary Vasospasm - etiology</topic><topic>Coronary Vessels - drug effects</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Injections, Intra-Arterial</topic><topic>Key words: vasospastic angina</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>Ultrasonography</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teragawa, Hiroki</creatorcontrib><creatorcontrib>Fukuda, Yukihiro</creatorcontrib><creatorcontrib>Matsuda, Keiji</creatorcontrib><creatorcontrib>Hirao, Hidekazu</creatorcontrib><creatorcontrib>Higashi, Yukihito</creatorcontrib><creatorcontrib>Yamagata, Togo</creatorcontrib><creatorcontrib>Oshima, Tetsuya</creatorcontrib><creatorcontrib>Matsuura, Hideo</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teragawa, Hiroki</au><au>Fukuda, Yukihiro</au><au>Matsuda, Keiji</au><au>Hirao, Hidekazu</au><au>Higashi, Yukihito</au><au>Yamagata, Togo</au><au>Oshima, Tetsuya</au><au>Matsuura, Hideo</au><au>Chayama, Kazuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial bridging increases the risk of coronary spasm</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>2003-08</date><risdate>2003</risdate><volume>26</volume><issue>8</issue><spage>377</spage><epage>383</epage><pages>377-383</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><coden>CLCADC</coden><abstract>Background: Myocardial bridging (MB) has been associated with cardiac events. Whether coronary spasm is one factor contributing to those events is unknown.
Hypothesis: This study investigated whether the likelihood of coronary spasm is increased in patients with MB.
Methods: A spasm‐provocation test was performed by infusing acetylcholine into the left coronary artery in 114 Japanese patients with chest pain. The test result was defined as positive when the diameter of the coronary artery was reduced by > 50% and ST‐segment changes were documented. Myocardial bridging was defined as a > 15% reduction in coronary arterial diameter during systole after intracoronary injection of nitroglycerin.
Results: Myocardial bridging was identified in 41 patients (36%) and was located in the mid‐segment of the left anterior descending coronary artery (LAD) in all patients. Patients with MB experienced coronary spasm more frequently than patients without MB (MB+: 73%; MB —: 40%, p = 0.0006). Furthermore, among patients with a positive spasm‐provocation test, coronary spasm occurred more frequently in the midsegment of the LAD in patients with MB than in those without MB (MB+: 73%; MB — : 45%, p = 0.0259). Multivariate regression analysis demonstrated that MB was a predictor of coronary spasm (odds ratio: 3.478, p = 0.0088).
Conclusions: These results suggest that MB increases the risk of coronary spasm and that coronary spasm may be the proximate etiology of cardiac events associated with MB.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>12918640</pmid><doi>10.1002/clc.4950260806</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Acetylcholine - administration & dosage Acetylcholine - pharmacology Angina Pectoris - complications Angina Pectoris - diagnosis Angina Pectoris - drug therapy Arteries - drug effects Biological and medical sciences cardiac sudden death Cardiology. Vascular system Clinical Investigation Clinical Investigations Coronary Angiography coronary artery Coronary heart disease Coronary Vasospasm - diagnosis Coronary Vasospasm - diagnostic imaging Coronary Vasospasm - etiology Coronary Vessels - drug effects Female Heart Humans Injections, Intra-Arterial Key words: vasospastic angina Male Medical sciences Middle Aged Nitroglycerin - administration & dosage Predictive Value of Tests Risk Factors Ultrasonography Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology |
| title | Myocardial bridging increases the risk of coronary spasm |
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