Transcoronary Infusion of Bone Marrow Derived Multipotent Stem Cells to Preserve Left Ventricular Geometry and Function After Myocardial Infarction
Background Myocardial damage after myocardial infarction (MI) was deemed irreversible after late reperfusion. Administration of multipotent stem cell (MSC) into such infarct may regenerate the myocardium and capillary network. Hypothesis Transcoronary infusion of bone marrow derived multipotent stem...
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| Veröffentlicht in: | Clinical cardiology (Mahwah, N.J.) N.J.), 2010-07, Vol.33 (7), p.E10-E15 |
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| container_title | Clinical cardiology (Mahwah, N.J.) |
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| creator | Boonbaichaiyapruck, Sarana Pienvichit, Pavit Limpijarnkij, Thosapol Rerkpattanapipat, Pairoj Pongpatananurak, Apichai Saelee, Ratchanee Ungkanont, Artit Hongeng, Suradej |
| description | Background
Myocardial damage after myocardial infarction (MI) was deemed irreversible after late reperfusion. Administration of multipotent stem cell (MSC) into such infarct may regenerate the myocardium and capillary network.
Hypothesis
Transcoronary infusion of bone marrow derived multipotent stem cells into infarcted related artery after acute myocardial infarction is feasible, safe and improve left ventricular function.
Methods
We conducted a pilot study in patients who survived ST‐elevation MI with late reperfusion therapy and remained hemodynamically stable. Bone marrow derived MSC was infused into a patent infarct‐related coronary artery during brief low pressure (2 atm) balloon inflation. A 3‐T gadolinium‐based MRI was performed at baseline and 8 weeks later to evaluate infarct area and LV function.
Results
We enrolled 10 patients, age 63.8 ± 2.8 years 5.2 ± 4.12 × 106 MSC were infused via coronary artery 24.8 ± 16 days after infarction. The procedures were successful in all patients without any in‐hospital event. Infarct size by MRI decreased by 5.84% (P = .018) over 8 weeks. Mean baseline left ventricular ejection fraction (LVEF) was 44.1% ± 9% and was 46.3% ± 9% at 8 weeks (P = .34). A trend of smaller LV end‐systolic volume with 65.02 ± 18.2 ml vs 63.04 ± 21.89 ml (P = .09) with no change of LV end‐diastolic volume observed.
Conclusion
MSC infusion into coronary circulation was feasible and safe after myocardial infarction. Infarct size was reduced with preservation of LV geometry. Copyright © 2010 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/clc.20545 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6653729</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733989070</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3295-6f5c61c5d2a2ac514f36c5ee108a54f8e4b16bd42d01b41bc7bab95abe8c258f3</originalsourceid><addsrcrecordid>eNp1kc1u1DAURi1ERaeFBS-AvEMs0tpOnJ8NUgm0VJoRSBS2luNcg5FjT21nqnmOvjCeTlu1C1Z3cY_Od3U_hN5SckIJYafKqhNGeMVfoAXtSla0Tdm8RAtCa1J0rO0O0VGMfzNKWla-QocZ5qzm9QLdXgXpovLBOxm2-NLpORrvsNf4k3eAVzIEf4M_QzAbGPFqtsmsfQKX8I8EE-7B2oiTx98DRAgbwEvQCf_KQDBqtjLgC_ATpCyXbsTns1NpF3CmEwS82nolw2ik3UXLcLd7jQ60tBHe3M9j9PP8y1X_tVh-u7jsz5aFKlnHi1pzVVPFRyaZVJxWuqwVB6CklbzSLVQDrYexYiOhQ0UH1Qxy6LgcoFWMt7o8Rh_33vU8TDCq3c3SinUwU_6F8NKI5xtn_ojffiPqmpcN67Lg_b0g-OsZYhKTiSp_RDrwcxRNWXZtRxqSyQ97UgUfYwD9mEKJ2HUocofirsPMvnt61iP5UFoGTvfAjbGw_b9J9Mt-r_wHk9iqwg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733989070</pqid></control><display><type>article</type><title>Transcoronary Infusion of Bone Marrow Derived Multipotent Stem Cells to Preserve Left Ventricular Geometry and Function After Myocardial Infarction</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Boonbaichaiyapruck, Sarana ; Pienvichit, Pavit ; Limpijarnkij, Thosapol ; Rerkpattanapipat, Pairoj ; Pongpatananurak, Apichai ; Saelee, Ratchanee ; Ungkanont, Artit ; Hongeng, Suradej</creator><creatorcontrib>Boonbaichaiyapruck, Sarana ; Pienvichit, Pavit ; Limpijarnkij, Thosapol ; Rerkpattanapipat, Pairoj ; Pongpatananurak, Apichai ; Saelee, Ratchanee ; Ungkanont, Artit ; Hongeng, Suradej</creatorcontrib><description>Background
Myocardial damage after myocardial infarction (MI) was deemed irreversible after late reperfusion. Administration of multipotent stem cell (MSC) into such infarct may regenerate the myocardium and capillary network.
Hypothesis
Transcoronary infusion of bone marrow derived multipotent stem cells into infarcted related artery after acute myocardial infarction is feasible, safe and improve left ventricular function.
Methods
We conducted a pilot study in patients who survived ST‐elevation MI with late reperfusion therapy and remained hemodynamically stable. Bone marrow derived MSC was infused into a patent infarct‐related coronary artery during brief low pressure (2 atm) balloon inflation. A 3‐T gadolinium‐based MRI was performed at baseline and 8 weeks later to evaluate infarct area and LV function.
Results
We enrolled 10 patients, age 63.8 ± 2.8 years 5.2 ± 4.12 × 106 MSC were infused via coronary artery 24.8 ± 16 days after infarction. The procedures were successful in all patients without any in‐hospital event. Infarct size by MRI decreased by 5.84% (P = .018) over 8 weeks. Mean baseline left ventricular ejection fraction (LVEF) was 44.1% ± 9% and was 46.3% ± 9% at 8 weeks (P = .34). A trend of smaller LV end‐systolic volume with 65.02 ± 18.2 ml vs 63.04 ± 21.89 ml (P = .09) with no change of LV end‐diastolic volume observed.
Conclusion
MSC infusion into coronary circulation was feasible and safe after myocardial infarction. Infarct size was reduced with preservation of LV geometry. Copyright © 2010 Wiley Periodicals, Inc.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.20545</identifier><identifier>PMID: 20552656</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Aged ; Bone Marrow Transplantation ; Clinical Investigation ; Clinical Investigations ; Contrast Media ; Feasibility Studies ; Female ; Gadolinium DTPA ; Heart Ventricles - pathology ; Heart Ventricles - physiopathology ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Multipotent Stem Cells - transplantation ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Myocardial Infarction - surgery ; Pilot Projects ; Stroke Volume ; Thailand ; Time Factors ; Treatment Outcome ; Ventricular Function, Left ; Ventricular Remodeling</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2010-07, Vol.33 (7), p.E10-E15</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>Copyright (c) 2010 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3295-6f5c61c5d2a2ac514f36c5ee108a54f8e4b16bd42d01b41bc7bab95abe8c258f3</citedby><cites>FETCH-LOGICAL-c3295-6f5c61c5d2a2ac514f36c5ee108a54f8e4b16bd42d01b41bc7bab95abe8c258f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653729/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653729/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27903,27904,45553,45554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20552656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boonbaichaiyapruck, Sarana</creatorcontrib><creatorcontrib>Pienvichit, Pavit</creatorcontrib><creatorcontrib>Limpijarnkij, Thosapol</creatorcontrib><creatorcontrib>Rerkpattanapipat, Pairoj</creatorcontrib><creatorcontrib>Pongpatananurak, Apichai</creatorcontrib><creatorcontrib>Saelee, Ratchanee</creatorcontrib><creatorcontrib>Ungkanont, Artit</creatorcontrib><creatorcontrib>Hongeng, Suradej</creatorcontrib><title>Transcoronary Infusion of Bone Marrow Derived Multipotent Stem Cells to Preserve Left Ventricular Geometry and Function After Myocardial Infarction</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Background
Myocardial damage after myocardial infarction (MI) was deemed irreversible after late reperfusion. Administration of multipotent stem cell (MSC) into such infarct may regenerate the myocardium and capillary network.
Hypothesis
Transcoronary infusion of bone marrow derived multipotent stem cells into infarcted related artery after acute myocardial infarction is feasible, safe and improve left ventricular function.
Methods
We conducted a pilot study in patients who survived ST‐elevation MI with late reperfusion therapy and remained hemodynamically stable. Bone marrow derived MSC was infused into a patent infarct‐related coronary artery during brief low pressure (2 atm) balloon inflation. A 3‐T gadolinium‐based MRI was performed at baseline and 8 weeks later to evaluate infarct area and LV function.
Results
We enrolled 10 patients, age 63.8 ± 2.8 years 5.2 ± 4.12 × 106 MSC were infused via coronary artery 24.8 ± 16 days after infarction. The procedures were successful in all patients without any in‐hospital event. Infarct size by MRI decreased by 5.84% (P = .018) over 8 weeks. Mean baseline left ventricular ejection fraction (LVEF) was 44.1% ± 9% and was 46.3% ± 9% at 8 weeks (P = .34). A trend of smaller LV end‐systolic volume with 65.02 ± 18.2 ml vs 63.04 ± 21.89 ml (P = .09) with no change of LV end‐diastolic volume observed.
Conclusion
MSC infusion into coronary circulation was feasible and safe after myocardial infarction. Infarct size was reduced with preservation of LV geometry. Copyright © 2010 Wiley Periodicals, Inc.</description><subject>Aged</subject><subject>Bone Marrow Transplantation</subject><subject>Clinical Investigation</subject><subject>Clinical Investigations</subject><subject>Contrast Media</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Heart Ventricles - pathology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging, Cine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multipotent Stem Cells - transplantation</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - surgery</subject><subject>Pilot Projects</subject><subject>Stroke Volume</subject><subject>Thailand</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Remodeling</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAURi1ERaeFBS-AvEMs0tpOnJ8NUgm0VJoRSBS2luNcg5FjT21nqnmOvjCeTlu1C1Z3cY_Od3U_hN5SckIJYafKqhNGeMVfoAXtSla0Tdm8RAtCa1J0rO0O0VGMfzNKWla-QocZ5qzm9QLdXgXpovLBOxm2-NLpORrvsNf4k3eAVzIEf4M_QzAbGPFqtsmsfQKX8I8EE-7B2oiTx98DRAgbwEvQCf_KQDBqtjLgC_ATpCyXbsTns1NpF3CmEwS82nolw2ik3UXLcLd7jQ60tBHe3M9j9PP8y1X_tVh-u7jsz5aFKlnHi1pzVVPFRyaZVJxWuqwVB6CklbzSLVQDrYexYiOhQ0UH1Qxy6LgcoFWMt7o8Rh_33vU8TDCq3c3SinUwU_6F8NKI5xtn_ojffiPqmpcN67Lg_b0g-OsZYhKTiSp_RDrwcxRNWXZtRxqSyQ97UgUfYwD9mEKJ2HUocofirsPMvnt61iP5UFoGTvfAjbGw_b9J9Mt-r_wHk9iqwg</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Boonbaichaiyapruck, Sarana</creator><creator>Pienvichit, Pavit</creator><creator>Limpijarnkij, Thosapol</creator><creator>Rerkpattanapipat, Pairoj</creator><creator>Pongpatananurak, Apichai</creator><creator>Saelee, Ratchanee</creator><creator>Ungkanont, Artit</creator><creator>Hongeng, Suradej</creator><general>Wiley Periodicals, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201007</creationdate><title>Transcoronary Infusion of Bone Marrow Derived Multipotent Stem Cells to Preserve Left Ventricular Geometry and Function After Myocardial Infarction</title><author>Boonbaichaiyapruck, Sarana ; Pienvichit, Pavit ; Limpijarnkij, Thosapol ; Rerkpattanapipat, Pairoj ; Pongpatananurak, Apichai ; Saelee, Ratchanee ; Ungkanont, Artit ; Hongeng, Suradej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3295-6f5c61c5d2a2ac514f36c5ee108a54f8e4b16bd42d01b41bc7bab95abe8c258f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Bone Marrow Transplantation</topic><topic>Clinical Investigation</topic><topic>Clinical Investigations</topic><topic>Contrast Media</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Heart Ventricles - pathology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging, Cine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multipotent Stem Cells - transplantation</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - surgery</topic><topic>Pilot Projects</topic><topic>Stroke Volume</topic><topic>Thailand</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boonbaichaiyapruck, Sarana</creatorcontrib><creatorcontrib>Pienvichit, Pavit</creatorcontrib><creatorcontrib>Limpijarnkij, Thosapol</creatorcontrib><creatorcontrib>Rerkpattanapipat, Pairoj</creatorcontrib><creatorcontrib>Pongpatananurak, Apichai</creatorcontrib><creatorcontrib>Saelee, Ratchanee</creatorcontrib><creatorcontrib>Ungkanont, Artit</creatorcontrib><creatorcontrib>Hongeng, Suradej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boonbaichaiyapruck, Sarana</au><au>Pienvichit, Pavit</au><au>Limpijarnkij, Thosapol</au><au>Rerkpattanapipat, Pairoj</au><au>Pongpatananurak, Apichai</au><au>Saelee, Ratchanee</au><au>Ungkanont, Artit</au><au>Hongeng, Suradej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcoronary Infusion of Bone Marrow Derived Multipotent Stem Cells to Preserve Left Ventricular Geometry and Function After Myocardial Infarction</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>2010-07</date><risdate>2010</risdate><volume>33</volume><issue>7</issue><spage>E10</spage><epage>E15</epage><pages>E10-E15</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><abstract>Background
Myocardial damage after myocardial infarction (MI) was deemed irreversible after late reperfusion. Administration of multipotent stem cell (MSC) into such infarct may regenerate the myocardium and capillary network.
Hypothesis
Transcoronary infusion of bone marrow derived multipotent stem cells into infarcted related artery after acute myocardial infarction is feasible, safe and improve left ventricular function.
Methods
We conducted a pilot study in patients who survived ST‐elevation MI with late reperfusion therapy and remained hemodynamically stable. Bone marrow derived MSC was infused into a patent infarct‐related coronary artery during brief low pressure (2 atm) balloon inflation. A 3‐T gadolinium‐based MRI was performed at baseline and 8 weeks later to evaluate infarct area and LV function.
Results
We enrolled 10 patients, age 63.8 ± 2.8 years 5.2 ± 4.12 × 106 MSC were infused via coronary artery 24.8 ± 16 days after infarction. The procedures were successful in all patients without any in‐hospital event. Infarct size by MRI decreased by 5.84% (P = .018) over 8 weeks. Mean baseline left ventricular ejection fraction (LVEF) was 44.1% ± 9% and was 46.3% ± 9% at 8 weeks (P = .34). A trend of smaller LV end‐systolic volume with 65.02 ± 18.2 ml vs 63.04 ± 21.89 ml (P = .09) with no change of LV end‐diastolic volume observed.
Conclusion
MSC infusion into coronary circulation was feasible and safe after myocardial infarction. Infarct size was reduced with preservation of LV geometry. Copyright © 2010 Wiley Periodicals, Inc.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>20552656</pmid><doi>10.1002/clc.20545</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aged Bone Marrow Transplantation Clinical Investigation Clinical Investigations Contrast Media Feasibility Studies Female Gadolinium DTPA Heart Ventricles - pathology Heart Ventricles - physiopathology Humans Magnetic Resonance Imaging, Cine Male Middle Aged Multipotent Stem Cells - transplantation Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - surgery Pilot Projects Stroke Volume Thailand Time Factors Treatment Outcome Ventricular Function, Left Ventricular Remodeling |
| title | Transcoronary Infusion of Bone Marrow Derived Multipotent Stem Cells to Preserve Left Ventricular Geometry and Function After Myocardial Infarction |
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