Age‐dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages

Progressive generation of total joint implant‐derived wear particles is one of the major risk factors in development of peri‐prosthetic osteolysis especially in the aging society. It is commonly accepted that macrophages predominantly drive the inflammatory response to wear debris particles. Among v...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-08, Vol.23 (8), p.5827-5831
Hauptverfasser:	Yamada, Chiaki, Beron‐Pelusso, Camila, Algazzaz, Neira, Heidari, Alireza, Luz, Diogo, Rawas‐Qalaji, Mutasem, Toderas, Ion, Mascarenhas, Ana Karina, Kawai, Toshihisa, Movila, Alexandru
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - metabolism Animals Antibodies, Monoclonal - pharmacology Antibodies, Neutralizing - pharmacology Bone cements Bone implants Cement Collagen Cytokines Detritus Gene expression Humans Inflammation Inflammation - pathology Inflammatory response Joint surgery Leukocyte migration Macrophage migration inhibitory factor Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism MARCO protein Mice Osteolysis Particulate matter Peritoneum Phagocytosis Phagocytosis - drug effects Polymethyl Methacrylate - chemistry Polymethylmethacrylate Receptors, Immunologic - metabolism Risk factors Senescence Short Communication Short Communications TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Transplants & implants Tumor necrosis factor Tumor necrosis factor-TNF Tumors Wear particles
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