Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping

Numerous pieces of evidence support the complex, 3D spatial organization of the genome dictates gene expression. CTCF is essential to define topologically associated domain boundaries and to facilitate the formation of insulated chromatin loop structures. To understand CTCF's direct role in glo...

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Veröffentlicht in:	Nucleic acids research 2019-07, Vol.47 (13), p.6699-6713
Hauptverfasser:	Hyle, Judith, Zhang, Yang, Wright, Shaela, Xu, Beisi, Shao, Ying, Easton, John, Tian, Liqing, Feng, Ruopeng, Xu, Peng, Li, Chunliang
Format:	Artikel
Sprache:	eng
Schlagworte:	CCCTC-Binding Factor - deficiency CCCTC-Binding Factor - physiology Cell Line, Tumor Cell Nucleus - metabolism Cell Nucleus - ultrastructure Chromatin - genetics Chromatin - ultrastructure Down-Regulation Enhancer Elements, Genetic - genetics Erythroid Precursor Cells - metabolism Gene Expression Regulation, Leukemic Gene Knock-In Techniques Gene regulation, Chromatin and Epigenetics Genes, myc Genes, Reporter Humans Nucleic Acid Conformation Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Promoter Regions, Genetic - genetics Proto-Oncogene Proteins c-myc - biosynthesis Transcriptome
Online-Zugang:	Volltext
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