Five Years of Successful Inducible Transgene Expression Following Locoregional Adeno-Associated Virus Delivery in Nonhuman Primates with No Detectable Immunity

Anti-transgene immune responses elicited after intramuscular (i.m.) delivery of recombinant adeno-associated virus (rAAV) have been shown to hamper long-term transgene expression in large-animal models of rAAV-mediated gene transfer. To overcome this hurdle, an alternative mode of delivery of rAAV v...

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Veröffentlicht in:	Human gene therapy 2019-07, Vol.30 (7), p.802-813
Hauptverfasser:	Guilbaud, Mickaël, Devaux, Marie, Couzinié, Celia, Le Duff, Johanne, Toromanoff, Alice, Vandamme, Céline, Jaulin, Nicolas, Gernoux, Gwladys, Larcher, Thibaut, Moullier, Philippe, Le Guiner, Caroline, Adjali, Oumeya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Viral - immunology Cytokines - metabolism Dependovirus - genetics Dependovirus - immunology Follow-Up Studies Gene Expression Gene transfer Gene Transfer Techniques Genetic Vectors - administration & dosage Genetic Vectors - adverse effects Genetic Vectors - genetics Genome, Viral Immune response Immune system Immunity Immunogenicity Intravenous administration Macaca fascicularis Monkeys Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Primates Skeletal muscle Time Factors Transgenes Vectors Viruses
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