Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants

Somatic mutations of calreticulin (CALR) have been described in approximately 60–80% of JAK2 and MPL unmutated Essential Thrombocythemia and Primary Myelofibrosis patients. CALR is an endoplasmic reticulum (ER) chaperone responsible for proper protein folding and calcium retention. Recent data demon...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10558-14, Article 10558
Hauptverfasser:	Salati, Simona, Genovese, Elena, Carretta, Chiara, Zini, Roberta, Bartalucci, Niccolò, Prudente, Zelia, Pennucci, Valentina, Ruberti, Samantha, Rossi, Chiara, Rontauroli, Sebastiano, Enzo, Elena, Calabresi, Laura, Balliu, Manjola, Mannarelli, Carmela, Bianchi, Elisa, Guglielmelli, Paola, Tagliafico, Enrico, Vannucchi, Alessandro M., Manfredini, Rossella
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 13/31 13/89 38/39 42/44 631/67/1990/2331 631/80/86/2366 82/1 82/80 96/95 Apoptosis Calcium Calreticulin Calreticulin - genetics Calreticulin - metabolism Cell Transformation, Neoplastic - genetics DNA damage DNA Repair - genetics Down-Regulation Endoplasmic reticulum Endoplasmic Reticulum Stress - genetics Gene Knockdown Techniques Genetic transformation Genomic instability Humanities and Social Sciences Humans INDEL Mutation Janus kinase 2 K562 Cells Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - genetics Molecular modelling multidisciplinary Mutant Proteins - genetics Mutant Proteins - metabolism Mutants Mutation Myelofibrosis Oxidative stress Oxidative Stress - genetics Phenanthrenes - pharmacology Primary Myelofibrosis - genetics Primary Myelofibrosis - metabolism Protein folding Proteins Recombinant Proteins - genetics Recombinant Proteins - metabolism Science Science (multidisciplinary) Superoxide Dismutase - metabolism Thrombocythemia, Essential - genetics Thrombocythemia, Essential - metabolism Transcriptome Unfolded Protein Response - genetics
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