Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells

We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and adventitial cell fraction. Here we further characterise PDGFRα/CD90-expressing cardiac MSCs (PDGFRα + cMSCs) a...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10579-17, Article 10579
Hauptverfasser:	Le, Thi Yen Loan, Pickett, Hilda A., Yang, Andrian, Ho, Joshua W. K., Thavapalachandran, Sujitha, Igoor, Sindhu, Yang, Sile F., Farraha, Melad, Voges, Holly K., Hudson, James E., dos Remedios, Cristobal G., Bryan, Tracy M., Kizana, Eddy, Chong, James J. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/31 13/51 14 14/19 14/63 45/77 45/91 631/532/2440 64 692/4019/592/2725 82 82/58 Angiogenesis Animals Cardiomyocytes CD90 antigen Cell differentiation Cell proliferation Cell survival Child Engraftment Heart Heart attacks Humanities and Social Sciences Humans Innate immunity Mass spectrometry Mass spectroscopy Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells - enzymology Mesenchyme Middle Aged multidisciplinary Myocardial infarction Myocardial Infarction - therapy Myocytes, Cardiac - enzymology Myocytes, Cardiac - transplantation Overexpression Paracrine signalling Platelet-derived growth factor Rats Receptor, Platelet-Derived Growth Factor alpha - metabolism RNA-directed DNA polymerase Science Science (multidisciplinary) Stromal cells Telomerase Telomerase - metabolism Telomerase reverse transcriptase Transplantation Ventricle
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