Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer

Background Gastric adenocarcinoma is a heterogenous disease that results from complex interactions between environmental and genetic factors, which may contribute to the disparate outcomes observed between different patient populations. This study aimed to determine whether genomic differences exist...

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Veröffentlicht in:	Annals of surgical oncology 2018-07, Vol.25 (7), p.2027-2033
Hauptverfasser:	van Beek, Elke J. A. H., Hernandez, Jonathan M., Goldman, Debra A., Davis, Jeremy L., McLaughlin, Kaitlin, Ripley, R. Taylor, Kim, Teresa S., Tang, Laura H., Hechtman, Jaclyn F., Zheng, Jian, Capanu, Marinela, Schultz, Nikolaus, Hyman, David M., Ladanyi, Marc, Berger, Michael F., Solit, David B., Janjigian, Yelena Y., Strong, Vivian E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - ethnology Adenocarcinoma - genetics Adenocarcinoma - pathology Adult African Americans African Americans - genetics Aged Aged, 80 and over Asian Continental Ancestry Group - genetics Biomarkers, Tumor - genetics Cancer Deoxyribonucleic acid DNA DNA Mutational Analysis - methods E-cadherin ErbB-3 protein European Continental Ancestry Group - genetics Female Follow-Up Studies Gastric cancer Gastrointestinal Oncology Genetic factors High-Throughput Nucleotide Sequencing Humans Male Medicine Medicine & Public Health Middle Aged Missense mutation Mutation Mutation rates Oncology p53 Protein Patients Population studies Prognosis Stomach Neoplasms - ethnology Stomach Neoplasms - genetics Stomach Neoplasms - pathology Surgery Surgical Oncology Tumor Suppressor Protein p53 - genetics Young Adult
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