Transcription preinitiation complex structure and dynamics provide insight into genetic diseases

Transcription preinitiation complexes (PICs) are vital assemblies whose function underlies the expression of protein-encoding genes. Cryo-EM advances have begun to uncover their structural organization. Nevertheless, functional analyses are hindered by incompletely modeled regions. Here we integrate...

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Veröffentlicht in:	Nature structural & molecular biology 2019-06, Vol.26 (6), p.397-406
Hauptverfasser:	Yan, Chunli, Dodd, Thomas, He, Yuan, Tainer, John A., Tsutakawa, Susan E., Ivanov, Ivaylo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/337/572 631/535/1258 Binding sites Biochemistry Biochemistry & Molecular Biology Biological Microscopy Biomedical and Life Sciences Biophysics Cell Biology Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Clustering Cockayne syndrome Communities Computer simulation Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA helicase Functional morphology Gene expression Gene mapping Gene mutations Genetic disorders Humans Life Sciences Mapping Membrane Biology Models, Molecular Mutation Protein interaction Protein Interaction Maps Protein Structure Protein Subunits - chemistry Protein Subunits - metabolism Proteins Rigging RNA polymerases Structure-function relationships Substrates Supercoiling Transcription Transcription Factor TFIIH - chemistry Transcription Factor TFIIH - metabolism Transcription factors Transcription Factors - chemistry Transcription Factors - metabolism Transcription Factors, TFII - chemistry Transcription Factors, TFII - metabolism Transcription Initiation, Genetic Trichothiodystrophy Xeroderma pigmentosum XPD protein
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