Characterization of T-Cell Receptor Repertoire in Patients with Rheumatoid Arthritis Receiving Biologic Therapies

Rheumatoid arthritis (RA) is a systematic autoimmune disease, predominantly causing chronic polyarticular inflammation and joint injury of patients. For the treatment of RA, biologic disease-modifying antirheumatic drugs (bDMARDs) have been used to reduce inflammation and to interfere with disease p...

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Veröffentlicht in:	Disease markers 2019, Vol.2019 (2019), p.1-12
Hauptverfasser:	Chang, Wei Chiao, Liu, Xiao, Wei, James Cheng-Chung, Wong, Henry Sung-Ching, Hsu, Yu-Wen, Chang, Che-Mai, Liao, Hsien-Tzung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Adult Aged Antirheumatic Agents - therapeutic use Arthritis Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoimmune diseases B cells Biodiversity Biological Therapy - methods Biomarkers - analysis Care and treatment Case-Control Studies CD20 antigen Complementarity-determining region 3 Cytokines Development and progression Disease Progression Drugs Female Follow-Up Studies Genes Health aspects Humans Immune system Immunology Immunosuppressive agents Inflammation Interleukin 6 Interleukin 6 receptors Lymphocytes Lymphocytes T Male Medical treatment Middle Aged Monoclonal antibodies Next-generation sequencing Pathogenesis Prognosis Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Rheumatoid arthritis Rheumatoid factor Rheumatology Rituximab Statistical analysis T cell receptors T cells Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-α
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