Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors

Abstract Context Aromatase deficiency causes obesity and insulin resistance in aromatase knockout mice and humans with rare mutations of the aromatase gene (CYP19). Aromatase inhibitors are a commonly prescribed therapy for postmenopausal breast cancer. Objective We hypothesized that aromatase inhib...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2019-09, Vol.104 (9), p.3670-3678
Hauptverfasser:	Gibb, Fraser W, Dixon, J Michael, Clarke, Catriona, Homer, Natalie Z, Faqehi, Abdullah M M, Andrew, Ruth, Walker, Brian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - drug effects Adiposity - drug effects Aged Aromatase Aromatase Inhibitors - adverse effects Biopsy Body composition Body fat Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Case-Control Studies Clinical s Dual energy X-ray absorptiometry Female Follow-Up Studies Glucose Glucose tolerance Glucose Tolerance Test Gonadal Steroid Hormones - blood Health risk assessment Humans Insulin Insulin - blood Insulin Resistance Leptin Leptin - blood Middle Aged Obesity Patients Post-menopause Postmenopause - drug effects Prognosis Transcription
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