Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides

Thiopeptides are natural antibiotics that are fashioned from short peptides by multiple layers of post-translational modification. Their biosynthesis, in particular the pyridine synthases that form the macrocyclic antibiotic core, has attracted intensive research but is complicated by the challenges...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2019-01, Vol.141 (2), p.758-762
Hauptverfasser:	Fleming, Steven R, Bartges, Tessa E, Vinogradov, Alexander A, Kirkpatrick, Christine L, Goto, Yuki, Suga, Hiroaki, Hicks, Leslie M, Bowers, Albert A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!