Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

Neuroinflammation is initiated in response to ischemic stroke, generally with the hallmarks of microglial activation and collateral brain injury contributed by robust inflammatory effects. Triggering receptor expressed on myeloid cells (TREM)-1, an amplifier of the innate immune response, is a criti...

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Veröffentlicht in:	Cell death & disease 2019-07, Vol.10 (8), p.555-17, Article 555
Hauptverfasser:	Xu, Pengfei, Zhang, Xiaohao, Liu, Qian, Xie, Yi, Shi, Xiaolei, Chen, Jingjing, Li, Yunzi, Guo, Hongquan, Sun, Rui, Hong, Ye, Liu, Xinfeng, Xu, Gelin
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 13/51 14/19 38/77 631/378/1934 631/80/82 82/80 96/1 96/109 96/95 Animals Antibodies Behavior, Animal - drug effects Biochemistry Biomedical and Life Sciences Brain injury Brain Ischemia - metabolism Caspase Caspase-1 Cell Biology Cell Culture Cerebral infarction Chemokines Disease Models, Animal Functional plasticity Immune response Immunology Inflammation Inflammation - metabolism Innate immunity Intercellular adhesion molecule 1 Intracellular Ischemia Kinases Life Sciences Male Mice Mice, Inbred C57BL Microglia Microglia - cytology Microglia - metabolism mRNA Myeloid cells Neutrophil Infiltration - drug effects NF-κB protein Oxazines - pharmacology Peroxidase Protein-tyrosine kinase Pyridines - pharmacology Pyroptosis Pyroptosis - drug effects Signal Transduction - drug effects Spleen Stroke Stroke - metabolism Syk Kinase - antagonists & inhibitors Syk Kinase - metabolism Syk protein Synaptic plasticity Transcriptome Triggering Receptor Expressed on Myeloid Cells-1 - antagonists & inhibitors Triggering Receptor Expressed on Myeloid Cells-1 - metabolism
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