Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

Cytosolic DNA triggers innate immune responses through the activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′,3′-cyclic GMP–AMP (cGAMP) 1 – 4 . 2′,3′-cGAMP is a potent inducer of immune signalling; however, no intracellular nucleases are known...

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Veröffentlicht in:	Nature (London) 2019-02, Vol.566 (7743), p.259-263
Hauptverfasser:	Eaglesham, James B., Pan, Youdong, Kupper, Thomas S., Kranzusch, Philip J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/262 631/326/596 631/45/535 82/80 Activation AMP Animals Baculoviridae - enzymology Baculovirus BASIC BIOLOGICAL SCIENCES Biochemistry Biological response modifiers Bonds (Securities) Butterflies Butterflies & moths Butterflies - enzymology Cell Line Cellular signal transduction Conserved Sequence Crystal structure Crystallography, X-Ray Cyclic GMP Cyclic guanosine monophosphate Degradation Deoxyribonucleases - chemistry Deoxyribonucleases - metabolism Deoxyribonucleic acid DNA DNA binding proteins DNA sequencing DNA, Viral - immunology Enzymes Female Gene deletion Genes Genes, Viral - genetics Genomes Genomics Homology Humanities and Social Sciences Humans Immune Evasion Immune response Immune system Immunity Immunity, Innate - immunology Infections Innate immunity Insects Interferon Intracellular signalling Kinases Letter Mammals Membrane Proteins - metabolism Methods Mice Mice, Inbred C57BL Models, Molecular Moths - enzymology multidisciplinary Nuclease Nucleases Nucleotides, Cyclic - metabolism Nucleotidyltransferases - metabolism Observations Proteins Science Science (multidisciplinary) Second Messenger Systems Signal Transduction - immunology Stimulators Structural biology Vaccinia Vaccinia virus - enzymology Vaccinia virus - genetics Vaccinia virus - growth & development Vaccinia virus - immunology Virology Virus replication Virus Replication - genetics Viruses
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