Magnetic Resonance Imaging Is More Sensitive Than PET for Detecting Treatment-Induced Cell Death-Dependent Changes in Glycolysis

Metabolic imaging has been widely used to measure the early responses of tumors to treatment. Here, we assess the abilities of PET measurement of [ F]FDG uptake and MRI measurement of hyperpolarized [1- C]pyruvate metabolism to detect early changes in glycolysis following treatment-induced cell deat...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-07, Vol.79 (14), p.3557-3569
Hauptverfasser:	Hesketh, Richard L, Wang, Jiazheng, Wright, Alan J, Lewis, David Y, Denton, Alice E, Grenfell, Richard, Miller, Jodi L, Bielik, Robert, Gehrung, Marcel, Fala, Maria, Ros, Susana, Xie, Bangwen, Hu, De-En, Brindle, Kevin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Animals Antineoplastic Agents - pharmacology Carbon Isotopes Cell Death - physiology Cell Line, Tumor Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Fluorodeoxyglucose F18 - pharmacokinetics Glycolysis - drug effects Heterografts Humans Lactic Acid - metabolism Magnetic Resonance Imaging - methods Mice, Inbred BALB C Mice, Nude Positron-Emission Tomography - methods Pyruvic Acid - metabolism Radiopharmaceuticals - pharmacokinetics Receptors, TNF-Related Apoptosis-Inducing Ligand - agonists Triple Negative Breast Neoplasms - diagnostic imaging Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology
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