Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India

Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis . There is an urgent need to understand the mechanisms by which the mutations confer resistance in order to identify new drug targets a...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10283-13, Article 10283
Hauptverfasser:	Munir, Asma, Kumar, Narender, Ramalingam, Suresh Babu, Tamilzhalagan, Sembulingam, Shanmugam, Siva Kumar, Palaniappan, Alangudi Natarajan, Nair, Dina, Priyadarshini, Padma, Natarajan, Mohan, Tripathy, Srikanth, Ranganathan, Uma Devi, Peacock, Sharon J., Parkhill, Julian, Blundell, Tom L., Malhotra, Sony
Format:	Artikel
Sprache:	eng
Schlagworte:	45 631/114/2410 631/208/737 631/535/1267 Adult Allosteric properties Allosteric Regulation - drug effects Antitubercular Agents - pharmacology Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Catalase - chemistry Catalase - genetics Catalase - metabolism DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Drug development Drug resistance Drug Resistance, Bacterial Genetic analysis Genomes Humanities and Social Sciences Humans India Isoniazid Isoniazid - pharmacology Learning algorithms Machine Learning Models, Molecular multidisciplinary Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Nucleotide sequence Protein Conformation Protein interaction Protein Stability - drug effects Proteins Rifampin Rifampin - pharmacology RpoB protein Science Science (multidisciplinary) Tuberculosis Tuberculosis - drug therapy Tuberculosis - microbiology Whole Genome Sequencing
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