Predicting factors of lateral neck lymph node metastases in patients with papillary thyroid microcarcinoma
The incidence of papillary thyroid microcarcinoma (PTMC) has increased dramatically in recent years. Compared with central lymph node metastases, lateral neck lymph node (LNLN) metastases in patients with PTMC were less studied. The aim of the present study is to analyze the predicting factors assoc...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-07, Vol.98 (27), p.e16386-e16386 |
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| creator | Wu, Xin Li, Binglu Zheng, Chaoji He, Xiaodong |
| description | The incidence of papillary thyroid microcarcinoma (PTMC) has increased dramatically in recent years. Compared with central lymph node metastases, lateral neck lymph node (LNLN) metastases in patients with PTMC were less studied. The aim of the present study is to analyze the predicting factors associated with LNLN metastases in patients with PTMC.A total of 3514 patients underwent thyroid surgery at our hospital from January 2017 to December 2017, and 936 patients with PTMC were selected and assessed retrospectively. They were further divided into 2 groups based on whether LNLN metastases existed or not. The relationship between LNLN metastases and clinicopathologic features of PTMC was analyzed.LNLN metastases were confirmed in 126 patients. Univariate and multivariate analyses found 5 independent factors associated with LNLN metastases. They were tumor size (≥0.7 cm) [odds ratio (OR) = 1.960, 95% confidence interval (95% CI) 1.227-3.131; P = .005], multifocality (OR = 2.254, 95% CI 1.398-3.634; P = .001), tumor location (upper portion) (OR = 6.312, 95% CI 3.853-10.340; P |
| doi_str_mv | 10.1097/MD.0000000000016386 |
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Compared with central lymph node metastases, lateral neck lymph node (LNLN) metastases in patients with PTMC were less studied. The aim of the present study is to analyze the predicting factors associated with LNLN metastases in patients with PTMC.A total of 3514 patients underwent thyroid surgery at our hospital from January 2017 to December 2017, and 936 patients with PTMC were selected and assessed retrospectively. They were further divided into 2 groups based on whether LNLN metastases existed or not. The relationship between LNLN metastases and clinicopathologic features of PTMC was analyzed.LNLN metastases were confirmed in 126 patients. Univariate and multivariate analyses found 5 independent factors associated with LNLN metastases. They were tumor size (≥0.7 cm) [odds ratio (OR) = 1.960, 95% confidence interval (95% CI) 1.227-3.131; P = .005], multifocality (OR = 2.254, 95% CI 1.398-3.634; P = .001), tumor location (upper portion) (OR = 6.312, 95% CI 3.853-10.340; P < .001), thyroid cancer family history (OR = 7.727, 95% CI 2.227-26.818; P = .001), and central lymph node metastases (OR = 11.810, 95% CI 6.547-21.302; P < .001).The findings of our study indicated that LNLN metastases were not rare in patients with PTMC, and tumor size (≥0.7 cm), multifocality, tumor location (upper portion), thyroid cancer family history, and central lymph node metastases were independent factors for LNLN metastases. In order to perform individualized management, LNLN should be meticulously evaluated when these features are detected.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000016386</identifier><identifier>PMID: 31277195</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Carcinoma, Papillary - diagnosis ; Carcinoma, Papillary - secondary ; Carcinoma, Papillary - therapy ; Female ; Humans ; Lymphatic Metastasis - pathology ; Male ; Middle Aged ; Neck ; Observational Study ; Retrospective Studies ; Risk Factors ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - secondary ; Thyroid Neoplasms - therapy ; Thyroidectomy ; Young Adult</subject><ispartof>Medicine (Baltimore), 2019-07, Vol.98 (27), p.e16386-e16386</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5000-624871af386e6f80b2e7dd3fbec458d7a0e994ac8a324c6ad0ee194d2561c1243</citedby><cites>FETCH-LOGICAL-c5000-624871af386e6f80b2e7dd3fbec458d7a0e994ac8a324c6ad0ee194d2561c1243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635253/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635253/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31277195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Xin</creatorcontrib><creatorcontrib>Li, Binglu</creatorcontrib><creatorcontrib>Zheng, Chaoji</creatorcontrib><creatorcontrib>He, Xiaodong</creatorcontrib><title>Predicting factors of lateral neck lymph node metastases in patients with papillary thyroid microcarcinoma</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The incidence of papillary thyroid microcarcinoma (PTMC) has increased dramatically in recent years. Compared with central lymph node metastases, lateral neck lymph node (LNLN) metastases in patients with PTMC were less studied. The aim of the present study is to analyze the predicting factors associated with LNLN metastases in patients with PTMC.A total of 3514 patients underwent thyroid surgery at our hospital from January 2017 to December 2017, and 936 patients with PTMC were selected and assessed retrospectively. They were further divided into 2 groups based on whether LNLN metastases existed or not. The relationship between LNLN metastases and clinicopathologic features of PTMC was analyzed.LNLN metastases were confirmed in 126 patients. Univariate and multivariate analyses found 5 independent factors associated with LNLN metastases. They were tumor size (≥0.7 cm) [odds ratio (OR) = 1.960, 95% confidence interval (95% CI) 1.227-3.131; P = .005], multifocality (OR = 2.254, 95% CI 1.398-3.634; P = .001), tumor location (upper portion) (OR = 6.312, 95% CI 3.853-10.340; P < .001), thyroid cancer family history (OR = 7.727, 95% CI 2.227-26.818; P = .001), and central lymph node metastases (OR = 11.810, 95% CI 6.547-21.302; P < .001).The findings of our study indicated that LNLN metastases were not rare in patients with PTMC, and tumor size (≥0.7 cm), multifocality, tumor location (upper portion), thyroid cancer family history, and central lymph node metastases were independent factors for LNLN metastases. In order to perform individualized management, LNLN should be meticulously evaluated when these features are detected.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - secondary</subject><subject>Carcinoma, Papillary - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Observational Study</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - secondary</subject><subject>Thyroid Neoplasms - therapy</subject><subject>Thyroidectomy</subject><subject>Young Adult</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1vFCEYhYnR2LX6C0wMl95M5ZuZGxPT-pW00Qu9Jiy806FlhhFYN_vvRbfWD0JCCM97OCcHoeeUnFEy6FdXF2fkz6KK9-oB2lDJVScHJR6iDSFMdnrQ4gQ9KeWmQVwz8RidcMq0poPcoJvPGXxwNSzXeLSuplxwGnG0FbKNeAF3i-NhXie8JA94hmpL21BwWPBqa4ClFrwPdWq3NcRo8wHX6ZBT8HgOLidnswtLmu1T9Gi0scCzu_MUfX339sv5h-7y0_uP528uOydbjk4x0WtqxxYH1NiTLQPtPR-34ITsvbYEhkFY11vOhFPWEwA6CM-koo4ywU_R66PuutvO4F1z2KKYNYe5mTPJBvPvyxImc52-G6W4ZJI3gZd3Ajl920GpZg7FQcu2QNoVwxrEek4oayg_oi1oKRnG-28oMT9bMlcX5v-W2tSLvx3ez_yupQHiCOxTbEWU27jbQzYT2FinX3pSD6xjhA5EE0m6pkwJ_wHa05_d</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Wu, Xin</creator><creator>Li, Binglu</creator><creator>Zheng, Chaoji</creator><creator>He, Xiaodong</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190701</creationdate><title>Predicting factors of lateral neck lymph node metastases in patients with papillary thyroid microcarcinoma</title><author>Wu, Xin ; Li, Binglu ; Zheng, Chaoji ; He, Xiaodong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5000-624871af386e6f80b2e7dd3fbec458d7a0e994ac8a324c6ad0ee194d2561c1243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Carcinoma, Papillary - secondary</topic><topic>Carcinoma, Papillary - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Observational Study</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - secondary</topic><topic>Thyroid Neoplasms - therapy</topic><topic>Thyroidectomy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xin</creatorcontrib><creatorcontrib>Li, Binglu</creatorcontrib><creatorcontrib>Zheng, Chaoji</creatorcontrib><creatorcontrib>He, Xiaodong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Xin</au><au>Li, Binglu</au><au>Zheng, Chaoji</au><au>He, Xiaodong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting factors of lateral neck lymph node metastases in patients with papillary thyroid microcarcinoma</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>98</volume><issue>27</issue><spage>e16386</spage><epage>e16386</epage><pages>e16386-e16386</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The incidence of papillary thyroid microcarcinoma (PTMC) has increased dramatically in recent years. Compared with central lymph node metastases, lateral neck lymph node (LNLN) metastases in patients with PTMC were less studied. The aim of the present study is to analyze the predicting factors associated with LNLN metastases in patients with PTMC.A total of 3514 patients underwent thyroid surgery at our hospital from January 2017 to December 2017, and 936 patients with PTMC were selected and assessed retrospectively. They were further divided into 2 groups based on whether LNLN metastases existed or not. The relationship between LNLN metastases and clinicopathologic features of PTMC was analyzed.LNLN metastases were confirmed in 126 patients. Univariate and multivariate analyses found 5 independent factors associated with LNLN metastases. They were tumor size (≥0.7 cm) [odds ratio (OR) = 1.960, 95% confidence interval (95% CI) 1.227-3.131; P = .005], multifocality (OR = 2.254, 95% CI 1.398-3.634; P = .001), tumor location (upper portion) (OR = 6.312, 95% CI 3.853-10.340; P < .001), thyroid cancer family history (OR = 7.727, 95% CI 2.227-26.818; P = .001), and central lymph node metastases (OR = 11.810, 95% CI 6.547-21.302; P < .001).The findings of our study indicated that LNLN metastases were not rare in patients with PTMC, and tumor size (≥0.7 cm), multifocality, tumor location (upper portion), thyroid cancer family history, and central lymph node metastases were independent factors for LNLN metastases. In order to perform individualized management, LNLN should be meticulously evaluated when these features are detected.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>31277195</pmid><doi>10.1097/MD.0000000000016386</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Carcinoma, Papillary - diagnosis Carcinoma, Papillary - secondary Carcinoma, Papillary - therapy Female Humans Lymphatic Metastasis - pathology Male Middle Aged Neck Observational Study Retrospective Studies Risk Factors Thyroid Neoplasms - diagnosis Thyroid Neoplasms - secondary Thyroid Neoplasms - therapy Thyroidectomy Young Adult |
| title | Predicting factors of lateral neck lymph node metastases in patients with papillary thyroid microcarcinoma |
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