Changing Paradigms of Periprocedural Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 3
To evaluate the changing paradigms of periprocedural antithrombotic management in neuroendovascular therapy in Japan, we analyzed the details of the current periprocedural antithrombotic therapy and compared it with those of the previous generations. We retrospectively analyzed the data from the Jap...
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| Veröffentlicht in: | Neurologia medico-chirurgica 2019, Vol.59(7), pp.247-256 |
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| creator | ENOMOTO, Yukiko MIZUTANI, Daisuke YOSHIMURA, Shinichi SAKAI, Nobuyuki Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators |
| description | To evaluate the changing paradigms of periprocedural antithrombotic management in neuroendovascular therapy in Japan, we analyzed the details of the current periprocedural antithrombotic therapy and compared it with those of the previous generations. We retrospectively analyzed the data from the Japanese Registry of Neuroendovascular Therapy (JR-NET) 3, a nationwide survey in Japan for neuroendovascular therapy between January 2010 and December 2014. A total of 26,233 patients underwent endovascular treatments to usually perform periprocedural antithrombotic therapy were retrospectively analyzed. We compared the results of JR-NET 3 with those of JR-NET 1 (January 2005 and December 2007) and JR-NET 2 (January 2008–December 2009). Post-procedural anticoagulant therapy was less utilized in JR-NET 3 than in JR-NET 2 (53.9% vs. 60.6%, P |
| doi_str_mv | 10.2176/nmc.st.2018-0265 |
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We retrospectively analyzed the data from the Japanese Registry of Neuroendovascular Therapy (JR-NET) 3, a nationwide survey in Japan for neuroendovascular therapy between January 2010 and December 2014. A total of 26,233 patients underwent endovascular treatments to usually perform periprocedural antithrombotic therapy were retrospectively analyzed. We compared the results of JR-NET 3 with those of JR-NET 1 (January 2005 and December 2007) and JR-NET 2 (January 2008–December 2009). Post-procedural anticoagulant therapy was less utilized in JR-NET 3 than in JR-NET 2 (53.9% vs. 60.6%, P <0.001). Pre-procedural antiplatelet therapy became more frequent and more intensive with each generation. The frequency of aggressive therapy (dual, and triple or more therapy) was 65.2% in JR-NET 3, which was significantly higher than that of JR-NET 1 and JR-NET 2 (41.5% and 61.2%, respectively, P <0.001). However, periprocedural ischemic complications (2.0% vs. 5.8%, P <0.001) significantly increased, despite aggressive antiplatelet therapy. Neuroendovascular periprocedural antithrombotic therapy is focused more on antiplatelet therapy than on anticoagulant therapy. Currently, antiplatelet therapy is more frequently used with a larger number of multiple agents, however, periprocedural ischemic complications significantly increased.</description><identifier>ISSN: 0470-8105</identifier><identifier>EISSN: 1349-8029</identifier><identifier>DOI: 10.2176/nmc.st.2018-0265</identifier><identifier>PMID: 31068546</identifier><language>eng</language><publisher>Japan: The Japan Neurosurgical Society</publisher><subject>anticoagulant ; Anticoagulants ; Anticoagulants - administration & dosage ; antiplatelet ; Cardiovascular system ; Cerebrovascular Disorders - surgery ; Endovascular Procedures ; Fibrinolytic Agents - administration & dosage ; Humans ; Ischemia ; Japan ; neuroendovascular therapy ; Neurosurgical Procedures ; Pharmacists ; Postoperative Complications - epidemiology ; Practice Patterns, Physicians ; Preoperative Care ; Registries ; Retrospective Studies ; Special Topic ; Surveys and Questionnaires</subject><ispartof>Neurologia medico-chirurgica, 2019, Vol.59(7), pp.247-256</ispartof><rights>2019 by The Japan Neurosurgical Society</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><rights>2019 The Japan Neurosurgical Society 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c742t-a6fae05875a1fe6dcb894163ca7daa440e6a900c452d6871e4b94d8a1fb6015d3</citedby><cites>FETCH-LOGICAL-c742t-a6fae05875a1fe6dcb894163ca7daa440e6a900c452d6871e4b94d8a1fb6015d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635149/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635149/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1877,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31068546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ENOMOTO, Yukiko</creatorcontrib><creatorcontrib>MIZUTANI, Daisuke</creatorcontrib><creatorcontrib>YOSHIMURA, Shinichi</creatorcontrib><creatorcontrib>SAKAI, Nobuyuki</creatorcontrib><creatorcontrib>Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</creatorcontrib><creatorcontrib>Department of Neurosurgery</creatorcontrib><creatorcontrib>Graduate School of Medicine</creatorcontrib><creatorcontrib>Hyogo College of Medicine</creatorcontrib><creatorcontrib>Kobe City Medical Center General Hospital</creatorcontrib><creatorcontrib>Gifu University</creatorcontrib><creatorcontrib>Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</creatorcontrib><title>Changing Paradigms of Periprocedural Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 3</title><title>Neurologia medico-chirurgica</title><addtitle>Neurol. Med. Chir.(Tokyo)</addtitle><description>To evaluate the changing paradigms of periprocedural antithrombotic management in neuroendovascular therapy in Japan, we analyzed the details of the current periprocedural antithrombotic therapy and compared it with those of the previous generations. We retrospectively analyzed the data from the Japanese Registry of Neuroendovascular Therapy (JR-NET) 3, a nationwide survey in Japan for neuroendovascular therapy between January 2010 and December 2014. A total of 26,233 patients underwent endovascular treatments to usually perform periprocedural antithrombotic therapy were retrospectively analyzed. We compared the results of JR-NET 3 with those of JR-NET 1 (January 2005 and December 2007) and JR-NET 2 (January 2008–December 2009). Post-procedural anticoagulant therapy was less utilized in JR-NET 3 than in JR-NET 2 (53.9% vs. 60.6%, P <0.001). Pre-procedural antiplatelet therapy became more frequent and more intensive with each generation. The frequency of aggressive therapy (dual, and triple or more therapy) was 65.2% in JR-NET 3, which was significantly higher than that of JR-NET 1 and JR-NET 2 (41.5% and 61.2%, respectively, P <0.001). However, periprocedural ischemic complications (2.0% vs. 5.8%, P <0.001) significantly increased, despite aggressive antiplatelet therapy. Neuroendovascular periprocedural antithrombotic therapy is focused more on antiplatelet therapy than on anticoagulant therapy. Currently, antiplatelet therapy is more frequently used with a larger number of multiple agents, however, periprocedural ischemic complications significantly increased.</description><subject>anticoagulant</subject><subject>Anticoagulants</subject><subject>Anticoagulants - administration & dosage</subject><subject>antiplatelet</subject><subject>Cardiovascular system</subject><subject>Cerebrovascular Disorders - surgery</subject><subject>Endovascular Procedures</subject><subject>Fibrinolytic Agents - administration & dosage</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Japan</subject><subject>neuroendovascular therapy</subject><subject>Neurosurgical Procedures</subject><subject>Pharmacists</subject><subject>Postoperative Complications - epidemiology</subject><subject>Practice Patterns, Physicians</subject><subject>Preoperative Care</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Special Topic</subject><subject>Surveys and Questionnaires</subject><issn>0470-8105</issn><issn>1349-8029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1r3DAQxU1paZY0956KoWdvR7I-7B4KYUnShJCGsj2LsSx7FbzSVrID-99Hzibb9CIJ5r3fzOhl2WcCS0qk-Oa2ehnHJQVSFUAFf5ctSMnqogJav88WwCQUFQF-kp3FaBsAyipWVvJjdlISEBVnYpG51QZdb12f32PA1vbbmPsuvzfB7oLXpp0CDvm5G-24CX7b-NHqfL0xAXf73Lr8zkzBG9f6R4x6GjC8Fr8nEw77aJ95N7-Lu4t1Xn7KPnQ4RHP2cp9mfy4v1qufxe2vq-vV-W2hJaNjgaJDA7ySHElnRKubqmZElBpli8gYGIE1gGactqKSxLCmZm2VxI0AwtvyNPtx4O6mZmtabdyY9lC7YLcY9sqjVf9XnN2o3j8qIUpOWJ0AX18Awf-dTBzVg59C2igqSmtKqGREJhUcVDr4GIPpjh0IqDkklUJSyTyHpOaQkuXL28mOhtdIkuDqIEhVq3HwbrDO_GuvW-LSp5uZWSsAXoNMF0l4lh6Ui7KkHChJpMsD6SGO2JtjKwwpxME8z8ZrJefj7YxHgd5gUMaVT0ydv8w</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>ENOMOTO, Yukiko</creator><creator>MIZUTANI, Daisuke</creator><creator>YOSHIMURA, Shinichi</creator><creator>SAKAI, Nobuyuki</creator><creator>Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</creator><general>The Japan Neurosurgical Society</general><general>THE JAPAN NEUROSURGICAL SOCIETY</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>2019</creationdate><title>Changing Paradigms of Periprocedural Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 3</title><author>ENOMOTO, Yukiko ; MIZUTANI, Daisuke ; YOSHIMURA, Shinichi ; SAKAI, Nobuyuki ; Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c742t-a6fae05875a1fe6dcb894163ca7daa440e6a900c452d6871e4b94d8a1fb6015d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>anticoagulant</topic><topic>Anticoagulants</topic><topic>Anticoagulants - administration & dosage</topic><topic>antiplatelet</topic><topic>Cardiovascular system</topic><topic>Cerebrovascular Disorders - surgery</topic><topic>Endovascular Procedures</topic><topic>Fibrinolytic Agents - administration & dosage</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Japan</topic><topic>neuroendovascular therapy</topic><topic>Neurosurgical Procedures</topic><topic>Pharmacists</topic><topic>Postoperative Complications - epidemiology</topic><topic>Practice Patterns, Physicians</topic><topic>Preoperative Care</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Special Topic</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ENOMOTO, Yukiko</creatorcontrib><creatorcontrib>MIZUTANI, Daisuke</creatorcontrib><creatorcontrib>YOSHIMURA, Shinichi</creatorcontrib><creatorcontrib>SAKAI, Nobuyuki</creatorcontrib><creatorcontrib>Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</creatorcontrib><creatorcontrib>Department of Neurosurgery</creatorcontrib><creatorcontrib>Graduate School of Medicine</creatorcontrib><creatorcontrib>Hyogo College of Medicine</creatorcontrib><creatorcontrib>Kobe City Medical Center General Hospital</creatorcontrib><creatorcontrib>Gifu University</creatorcontrib><creatorcontrib>Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurologia medico-chirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ENOMOTO, Yukiko</au><au>MIZUTANI, Daisuke</au><au>YOSHIMURA, Shinichi</au><au>SAKAI, Nobuyuki</au><au>Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</au><aucorp>Department of Neurosurgery</aucorp><aucorp>Graduate School of Medicine</aucorp><aucorp>Hyogo College of Medicine</aucorp><aucorp>Kobe City Medical Center General Hospital</aucorp><aucorp>Gifu University</aucorp><aucorp>Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing Paradigms of Periprocedural Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 3</atitle><jtitle>Neurologia medico-chirurgica</jtitle><addtitle>Neurol. Med. Chir.(Tokyo)</addtitle><date>2019</date><risdate>2019</risdate><volume>59</volume><issue>7</issue><spage>247</spage><epage>256</epage><pages>247-256</pages><issn>0470-8105</issn><eissn>1349-8029</eissn><abstract>To evaluate the changing paradigms of periprocedural antithrombotic management in neuroendovascular therapy in Japan, we analyzed the details of the current periprocedural antithrombotic therapy and compared it with those of the previous generations. We retrospectively analyzed the data from the Japanese Registry of Neuroendovascular Therapy (JR-NET) 3, a nationwide survey in Japan for neuroendovascular therapy between January 2010 and December 2014. A total of 26,233 patients underwent endovascular treatments to usually perform periprocedural antithrombotic therapy were retrospectively analyzed. We compared the results of JR-NET 3 with those of JR-NET 1 (January 2005 and December 2007) and JR-NET 2 (January 2008–December 2009). Post-procedural anticoagulant therapy was less utilized in JR-NET 3 than in JR-NET 2 (53.9% vs. 60.6%, P <0.001). Pre-procedural antiplatelet therapy became more frequent and more intensive with each generation. The frequency of aggressive therapy (dual, and triple or more therapy) was 65.2% in JR-NET 3, which was significantly higher than that of JR-NET 1 and JR-NET 2 (41.5% and 61.2%, respectively, P <0.001). However, periprocedural ischemic complications (2.0% vs. 5.8%, P <0.001) significantly increased, despite aggressive antiplatelet therapy. Neuroendovascular periprocedural antithrombotic therapy is focused more on antiplatelet therapy than on anticoagulant therapy. Currently, antiplatelet therapy is more frequently used with a larger number of multiple agents, however, periprocedural ischemic complications significantly increased.</abstract><cop>Japan</cop><pub>The Japan Neurosurgical Society</pub><pmid>31068546</pmid><doi>10.2176/nmc.st.2018-0265</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | anticoagulant Anticoagulants Anticoagulants - administration & dosage antiplatelet Cardiovascular system Cerebrovascular Disorders - surgery Endovascular Procedures Fibrinolytic Agents - administration & dosage Humans Ischemia Japan neuroendovascular therapy Neurosurgical Procedures Pharmacists Postoperative Complications - epidemiology Practice Patterns, Physicians Preoperative Care Registries Retrospective Studies Special Topic Surveys and Questionnaires |
| title | Changing Paradigms of Periprocedural Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 3 |
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