Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase

BACKGROUND:The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the mechanisms of its therapeutic actions. The polyphenolic rings of resveratrol enable it to react with and detoxify otherwise injurious oxidants. W...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2019-07, Vol.140 (2), p.126-137
Hauptverfasser:	Prysyazhna, Oleksandra, Wolhuter, Kathryn, Switzer, Christopher, Santos, Celio, Yang, Xiaoping, Lynham, Steven, Shah, Ajay M, Eaton, Philip, Burgoyne, Joseph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Blood Pressure - drug effects Blood Pressure - physiology Cells, Cultured Cyclic GMP-Dependent Protein Kinase Type I - metabolism Humans Mice Mice, Transgenic Organ Culture Techniques Original s Oxidation-Reduction - drug effects Oxidative Stress - drug effects Oxidative Stress - physiology Rats Resveratrol - pharmacology Telemetry - methods
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