Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer

Breast cancers with alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely, and molecular features contributing to this variability remain unknown. We hypothesiz...

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Veröffentlicht in:	Clinical cancer research 2019-07, Vol.25 (14), p.4363-4374
Hauptverfasser:	Kraya, Adam A, Maxwell, Kara N, Wubbenhorst, Bradley, Wenz, Brandon M, Pluta, John, Rech, Andrew J, Dorfman, Liza M, Lunceford, Nicole, Barrett, Amanda, Mitra, Nandita, Morrissette, Jennifer J D, Feldman, Michael, Nayak, Anupma, Domchek, Susan M, Vonderheide, Robert H, Nathanson, Katherine L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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