Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo

Global brain state dynamics regulate plasticity in local cortical circuits, but the underlying cellular and molecular mechanisms are unclear. Here, we demonstrate that astrocyte Ca(2+) signaling provides a critical bridge between cholinergic activation, associated with attention and vigilance states...

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Veröffentlicht in:	The Journal of neuroscience 2011-12, Vol.31 (49), p.18155-18165
Hauptverfasser:	Takata, Norio, Mishima, Tsuneko, Hisatsune, Chihiro, Nagai, Terumi, Ebisui, Etsuko, Mikoshiba, Katsuhiko, Hirase, Hajime
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Action Potentials - drug effects Action Potentials - genetics Afferent Pathways - physiology Aniline Compounds - metabolism Animals Astrocytes - drug effects Astrocytes - physiology Atropine - pharmacology Basal Nucleus of Meynert - physiology Calcium Signaling - drug effects Calcium Signaling - genetics Calcium Signaling - physiology Cholinergic Agents - metabolism Chromatography, High Pressure Liquid Evoked Potentials, Somatosensory - drug effects Evoked Potentials, Somatosensory - genetics Excitatory Amino Acid Antagonists - pharmacology Fluoresceins - metabolism Inositol 1,4,5-Trisphosphate Receptors - deficiency Male Mice Mice, Knockout Microdialysis - methods Muscarinic Antagonists - pharmacology Nerve Growth Factors - metabolism Neuronal Plasticity - drug effects Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurons - drug effects Neurons - metabolism Physical Stimulation Piperazines - pharmacology S100 Calcium Binding Protein beta Subunit S100 Proteins - metabolism Serine - pharmacology Somatosensory Cortex - drug effects Somatosensory Cortex - physiology Sulfonamides - metabolism Thiazoles - metabolism Vibrissae - innervation
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