Loss of quinone reductase 2 function selectively facilitates learning behaviors

High levels of reactive oxygen species (ROS) are associated with deficits in learning and memory with age as well as in Alzheimer's disease. Using DNA microarray, we demonstrated the overexpression of quinone reductase 2 (QR2) in the hippocampus in two models of learning deficits, namely the ag...

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Veröffentlicht in:	The Journal of neuroscience 2010-09, Vol.30 (38), p.12690-12700
Hauptverfasser:	Benoit, Charles-Etienne, Bastianetto, Stephane, Brouillette, Jonathan, Tse, YiuChung, Boutin, Jean A, Delagrange, Philippe, Wong, TakPan, Sarret, Philippe, Quirion, Rémi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Behavior, Animal - drug effects Behavior, Animal - physiology Exploratory Behavior - drug effects Exploratory Behavior - physiology Hippocampus - drug effects Hippocampus - metabolism Humans Immunohistochemistry Learning - drug effects Learning - physiology Male Mice Mice, Knockout Neurons - drug effects Neurons - metabolism Pyridines - pharmacology Pyrrolizidine Alkaloids - pharmacology Quinone Reductases - antagonists & inhibitors Quinone Reductases - genetics Quinone Reductases - metabolism Rats Rats, Long-Evans Rats, Sprague-Dawley Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Reverse Transcriptase Polymerase Chain Reaction Rotarod Performance Test Swimming
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