Loss of Cav1.3 Channels Reveals the Critical Role of L-Type and BK Channel Coupling in Pacemaking Mouse Adrenal Chromaffin Cells

We studied wild-type (WT) and Cav1.3(-/-) mouse chromaffin cells (MCCs) with the aim to determine the isoform of L-type Ca(2+) channel (LTCC) and BK channels that underlie the pacemaker current controlling spontaneous firing. Most WT-MCCs (80%) were spontaneously active (1.5 Hz) and highly sensitive...

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Veröffentlicht in:	The Journal of neuroscience 2010-01, Vol.30 (2), p.491-504
Hauptverfasser:	Marcantoni, Andrea, Vandael, David H. F, Mahapatra, Satyajit, Carabelli, Valentina, Sinnegger-Brauns, Martina J, Striessnig, Joerg, Carbone, Emilio
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Adrenal Cortex - metabolism Adrenal Medulla - cytology Animals Biophysical Phenomena - drug effects Biophysical Phenomena - genetics Biophysics Calcium Channel Agonists - pharmacology Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - deficiency Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Cells, Cultured Chelating Agents - pharmacology Chromaffin Cells - drug effects Chromaffin Cells - physiology Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Electric Stimulation - methods Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Indoles - pharmacology Ionophores - pharmacology Large-Conductance Calcium-Activated Potassium Channels - genetics Large-Conductance Calcium-Activated Potassium Channels - metabolism Membrane Potentials - drug effects Membrane Potentials - genetics Mice Mice, Knockout Patch-Clamp Techniques Potassium Channel Blockers - pharmacology Spider Venoms - pharmacology Time Factors
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