Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity

In our previous study, we clearly demonstrated the roles of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), and IL-6, and subsequent reactive oxygen species (ROS) generation on the pathogenesis of cisplatin ototoxicity in vitro and in vivo. ROS genera...

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Veröffentlicht in:	The Journal of neuroscience 2010-03, Vol.30 (11), p.3933-3946
Hauptverfasser:	Kim, Hyung-Jin, Lee, Jeong-Han, Kim, Se-Jin, Oh, Gi Su, Moon, Hae-Dalma, Kwon, Kang-Beom, Park, Channy, Park, Byung Hyun, Lee, Ho-Kyun, Chung, Sang-Young, Park, Raekil, So, Hong-Seob
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Cell Line, Transformed Cisplatin - administration & dosage Cisplatin - antagonists & inhibitors Cisplatin - toxicity Hair Cells, Auditory, Outer - drug effects Hair Cells, Auditory, Outer - enzymology Hearing Loss - chemically induced Hearing Loss - metabolism Injections, Intraperitoneal Male Mice Mice, Inbred BALB C NADPH Oxidases - physiology Organ Culture Techniques Oxidative Stress - drug effects Oxidative Stress - physiology Random Allocation Rats Rats, Sprague-Dawley Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism
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