Acid Base Balance and Progression of Kidney Disease
A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered ran...
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| Veröffentlicht in: | Seminars in nephrology 2019-07, Vol.39 (4), p.406-417 |
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| creator | Chen, Wei Levy, David S. Abramowitz, Matthew K. |
| description | A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology. |
| doi_str_mv | 10.1016/j.semnephrol.2019.04.009 |
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Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology.</description><identifier>ISSN: 0270-9295</identifier><identifier>EISSN: 1558-4488</identifier><identifier>DOI: 10.1016/j.semnephrol.2019.04.009</identifier><identifier>PMID: 31300095</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acidosis ; alkali therapy ; alkalosis ; Ammonia - urine ; Animals ; Biomarkers - urine ; chronic ; Disease Progression ; Humans ; kidney disease progression ; Kidney Diseases - drug therapy ; Kidney Diseases - physiopathology ; Renal insufficiency</subject><ispartof>Seminars in nephrology, 2019-07, Vol.39 (4), p.406-417</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. 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Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related to acidosis is not straightforward, and that application of urine markers such as ammonium may require more nuance than would be predicted based on our understanding of the pathophysiology.</description><subject>Acidosis</subject><subject>alkali therapy</subject><subject>alkalosis</subject><subject>Ammonia - urine</subject><subject>Animals</subject><subject>Biomarkers - urine</subject><subject>chronic</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>kidney disease progression</subject><subject>Kidney Diseases - drug therapy</subject><subject>Kidney Diseases - physiopathology</subject><subject>Renal insufficiency</subject><issn>0270-9295</issn><issn>1558-4488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOHDEQRS0EChOSX0C9ZNOd8qttb5B45CWQyCKsLbddDR71tAd7Bom_j9EASVZs7IVP3es6hDQUOgq0_7LsCq5mXN_nNHUMqOlAdABmjyyolLoVQut9sgCmoDXMyEPysZQlAKOK0Q_kkFMOFZcLws98DM25K1iPyc0eGzeH5ldOdxlLiWlu0thcxTDjU3MZC1byEzkY3VTw88t9RG6_ff198aO9vvn-8-LsuvVCmU0ruXKOiqCcpgN4E_woa6lm2jgUjHrgTA6O0aEfRgoIXGvBfVBeCzFKxY_I6S53vR1WGDzOm-wmu85x5fKTTS7a_1_meG_v0qPte2YE72vAyUtATg9bLBu7isXjVPfEtC2WMakUKKN0RfUO9TmVknF8q6Fgn53bpf3r3D47tyBs3aeOHv_7zbfBV8kVON8BWGU9Rsy2-IhVdYgZ_caGFN9v-QPxsZeN</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Chen, Wei</creator><creator>Levy, David S.</creator><creator>Abramowitz, Matthew K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201907</creationdate><title>Acid Base Balance and Progression of Kidney Disease</title><author>Chen, Wei ; Levy, David S. ; Abramowitz, Matthew K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-537aa14d7a81b0c9dcf50098289ae421c0325ba21b6bf10e038843cd7c844f573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acidosis</topic><topic>alkali therapy</topic><topic>alkalosis</topic><topic>Ammonia - urine</topic><topic>Animals</topic><topic>Biomarkers - urine</topic><topic>chronic</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>kidney disease progression</topic><topic>Kidney Diseases - drug therapy</topic><topic>Kidney Diseases - physiopathology</topic><topic>Renal insufficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Levy, David S.</creatorcontrib><creatorcontrib>Abramowitz, Matthew K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wei</au><au>Levy, David S.</au><au>Abramowitz, Matthew K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acid Base Balance and Progression of Kidney Disease</atitle><jtitle>Seminars in nephrology</jtitle><addtitle>Semin Nephrol</addtitle><date>2019-07</date><risdate>2019</risdate><volume>39</volume><issue>4</issue><spage>406</spage><epage>417</epage><pages>406-417</pages><issn>0270-9295</issn><eissn>1558-4488</eissn><abstract>A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. 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| identifier | ISSN: 0270-9295 |
| ispartof | Seminars in nephrology, 2019-07, Vol.39 (4), p.406-417 |
| issn | 0270-9295 1558-4488 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acidosis alkali therapy alkalosis Ammonia - urine Animals Biomarkers - urine chronic Disease Progression Humans kidney disease progression Kidney Diseases - drug therapy Kidney Diseases - physiopathology Renal insufficiency |
| title | Acid Base Balance and Progression of Kidney Disease |
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