Critical role of IL-21 and T follicular helper cells in hypertension and vascular dysfunction

T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce IL-21 promote germinal center (GC) B cell responses, leading to Ig production. Here we investigate the role of IL-21 and Tfh ce...

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Veröffentlicht in:	JCI insight 2019-06, Vol.4 (11)
Hauptverfasser:	Dale, Bethany L., Pandey, Arvind K., Chen, Yuhan, Smart, Charles D., Laroumanie, Fanny, Ao, Mingfang, Xiao, Liang, Dikalova, Anna E., Dikalov, Sergey I., Elijovich, Fernando, Foss, Jason D., Barbaro, Natalia R., Van Beusecum, Justin P., Deger, Serpil M., Alsouqi, Aseel, Itani, Hana A., Norlander, Allison E., Alexander, Matthew R., Zhao, Shilin, Ikizler, T. Alp, Algood, Holly M. Scott, Madhur, Meena S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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