Human Cancer Cell Membrane-Coated Biomimetic Nanoparticles Reduce Fibroblast-Mediated Invasion and Metastasis and Induce T‑Cells

Biomimetic nanoparticles (NPs) combine the flexibility and reproducibility of synthetic materials with the functionality of biological materials. Here, we developed and characterized biomimetic poly(lactic-co-glycolic acid) (PLGA) NPs coated with human cancer cell membrane fractions (CCMFs) to form...

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Veröffentlicht in:	ACS applied materials & interfaces 2019-02, Vol.11 (8), p.7850-7861
Hauptverfasser:	Jin, Jiefu, Krishnamachary, Balaji, Barnett, James D, Chatterjee, Samit, Chang, Di, Mironchik, Yelena, Wildes, Flonne, Jaffee, Elizabeth M, Nimmagadda, Sridhar, Bhujwalla, Zaver M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetic Materials - chemistry Biomimetic Materials - metabolism Biomimetic Materials - pharmacology Biomimetic Materials - therapeutic use Breast Neoplasms - pathology CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cell Membrane - chemistry Cell Movement - drug effects Female Fibroblasts - cytology Fibroblasts - metabolism Humans Hyaluronan Receptors - chemistry Interferon-gamma - metabolism Lung Neoplasms - pathology Lung Neoplasms - prevention & control Lung Neoplasms - secondary Lymph Nodes - metabolism Mice Mice, Inbred BALB C Nanoparticles - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Receptors, CXCR4 - chemistry
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