The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines

Most normal and tumor cells are protected from tumor necrosis factor α (TNFα)-induced apoptosis. Here, we identify the MAP3 kinase tumor progression locus-2 (TPL2) as a player contributing to the protection of a subset of tumor cell lines. The combination of TPL2 knockdown and TNFα gives rise to a s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-07, Vol.116 (28), p.14039-14048
Hauptverfasser:	Serebrennikova, Oksana B., Paraskevopoulou, Maria D., Aguado-Fraile, Elia, Taraslia, Vasiliki, Ren, Wenying, Thapa, Geeta, Roper, Jatin, Du, Keyong, Croce, Carlo M., Tsichlis, Philip N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Biological Sciences Biotechnology c-FLIP protein Carcinoma - drug therapy Carcinoma - genetics Carcinoma - pathology Caspase Caspase 8 - genetics Caspase Inhibitors - pharmacology Caspase-8 Cell activation Clustering Drug Resistance, Neoplasm - genetics Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques HeLa Cells Humans Kinases Lethality Macrophages - metabolism MAP Kinase Kinase Kinases - antagonists & inhibitors MAP Kinase Kinase Kinases - genetics MicroRNAs - genetics Phenotypes Phosphorylation - drug effects PNAS Plus Protein kinase Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors Receptor-Interacting Protein Serine-Threonine Kinases - genetics RNA, Small Interfering - genetics Signal Transduction siRNA Synthetic Lethal Mutations - genetics Threonine Tumor cell lines Tumor cells Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!