Proteasome and Autophagy-Mediated Impairment of Late Long-Term Potentiation (l-LTP) after Traumatic Brain Injury in the Somatosensory Cortex of Mice

Traumatic brain injury (TBI) can lead to impaired cognition and memory consolidation. The acute phase (24-48 h) after TBI is often characterized by neural dysfunction in the vicinity of the lesion, but also in remote areas like the contralateral hemisphere. Protein homeostasis is crucial for synapti...

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Veröffentlicht in:	International journal of molecular sciences 2019-06, Vol.20 (12), p.3048
Hauptverfasser:	Feldmann, Lucia K, Le Prieult, Florie, Felzen, Vanessa, Thal, Serge C, Engelhard, Kristin, Behl, Christian, Mittmann, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Apoptosis Autophagy Brain damage Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - physiopathology Ca2+/calmodulin-dependent protein kinase II Calcium Homeostasis Isoforms Kinases Long-Term Potentiation Mice, Inbred C57BL Nanoparticles Neuronal Plasticity Neuroplasticity Neurotransmission Phagocytosis Phosphorylation Proteasome Endopeptidase Complex - metabolism Proteasomes Protein synthesis Proteins Proteolysis Rapamycin Somatosensory cortex Somatosensory Cortex - metabolism Somatosensory Cortex - physiopathology Stimulation Synapse elimination Synaptic plasticity Synaptogenesis TOR protein Traumatic brain injury
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