Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen

Cisplatin and several non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to act synergistically or at least additively on several tumor cell lines. Dual-action cisplatin-based Pt(IV) combos containing ketoprofen and naproxen offer good antiproliferative performance on a panel of human t...

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Veröffentlicht in:	International journal of molecular sciences 2019-06, Vol.20 (12), p.3074
Hauptverfasser:	Ravera, Mauro, Zanellato, Ilaria, Gabano, Elisabetta, Perin, Elena, Rangone, Beatrice, Coppola, Marco, Osella, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylsalicylic acid Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferatives Aspirin Cancer therapies Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Ethanol High-performance liquid chromatography Humans Inflammation Inhibitory Concentration 50 Ketoprofen Ketoprofen - chemistry Ketoprofen - pharmacology Ligands Lipophilic Medical prognosis Molecular Structure Molecular weight Naproxen Naproxen - chemistry Naproxen - pharmacology NMR Nonsteroidal anti-inflammatory drugs Nuclear magnetic resonance Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Prodrugs - chemistry Prodrugs - pharmacology Reaction kinetics Tumors
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