Curcumin attenuates hypoxia/reoxygenation‑induced cardiomyocyte injury by downregulating Notch signaling

Recovery of the blood supply is the most effective treatment against ischemic heart disease; however, it is also a major cause of myocardial ischemia/reperfusion injury in clinical therapy. Curcumin has been reported to possess beneficial effects against hypoxia/reoxygenation (H/R)‑induced cardiomyo...

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Veröffentlicht in:	Molecular medicine reports 2019-08, Vol.20 (2), p.1541-1550
Hauptverfasser:	Zhu, Peng, Yang, Manli, He, Hao, Kuang, Zhibin, Liang, Mu, Lin, Anxiao, Liang, Song, Wen, Qiyun, Cheng, Zhiqin, Sun, Chaofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antioxidants Antioxidants (Nutrients) Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cardiomyocytes Cardiovascular diseases Cell cycle Cell growth Cell Hypoxia Cell injury Cell Line Cell proliferation Cell Survival - drug effects Cell viability Coronary artery disease Curcumin Curcumin - pharmacology Dehydrogenases Enhancer-of-split protein Enzymatic activity Enzymes Flow cytometry Gene expression Gene Expression Regulation Genes Heart cells Heart diseases Hypotheses Hypoxia Intracellular Ischemia Jagged-1 Protein - pharmacology Jagged1 protein L-Lactate dehydrogenase L-Lactate Dehydrogenase - genetics L-Lactate Dehydrogenase - metabolism Lactic acid Ligands Malondialdehyde Malondialdehyde - antagonists & inhibitors Malondialdehyde - metabolism Mammals Molecular modelling Myocardial ischemia Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxygen - pharmacology Polymerase chain reaction Proteins Rats Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Receptors, Notch - antagonists & inhibitors Receptors, Notch - genetics Receptors, Notch - metabolism Reperfusion Repressor Proteins - genetics Repressor Proteins - metabolism Reverse transcription Scientific equipment industry Signal Transduction - drug effects Signal Transduction - genetics Studies Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxides Transcription (Genetics) Transcription Factor HES-1 - genetics Transcription Factor HES-1 - metabolism Western blotting
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