Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription
A major event in the maturation of CNS GABAergic transmission is the qualitative change in GABA(A)-mediated responses from depolarizing to hyperpolarizing. In cortical regions, this is attributed to the increased expression of potassium chloride cotransporter 2b (KCC2b), the main isoform of the neur...
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| Veröffentlicht in: | The Journal of neuroscience 2011-01, Vol.31 (2), p.644-649 |
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| creator | Ludwig, Anastasia Uvarov, Pavel Soni, Shetal Thomas-Crusells, Judith Airaksinen, Matti S Rivera, Claudio |
| description | A major event in the maturation of CNS GABAergic transmission is the qualitative change in GABA(A)-mediated responses from depolarizing to hyperpolarizing. In cortical regions, this is attributed to the increased expression of potassium chloride cotransporter 2b (KCC2b), the main isoform of the neuron-specific K-Cl cotransporter KCC2. We have previously shown that transcription factor early growth response 4 (Egr4) can activate the KCC2b promoter. Here we demonstrate that in immature hippocampal neurons BDNF robustly induces ERK1/2 (extracellular signal-regulated kinase 1/2)-dependent Egr4 expression and rapid Egr4-dependent activation of the KCC2b promoter. The subsequent increase in KCC2b mRNA contributes to the expression of total KCC2 protein levels. These results indicate that Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons. |
| doi_str_mv | 10.1523/JNEUROSCI.2006-10.2011 |
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In cortical regions, this is attributed to the increased expression of potassium chloride cotransporter 2b (KCC2b), the main isoform of the neuron-specific K-Cl cotransporter KCC2. We have previously shown that transcription factor early growth response 4 (Egr4) can activate the KCC2b promoter. Here we demonstrate that in immature hippocampal neurons BDNF robustly induces ERK1/2 (extracellular signal-regulated kinase 1/2)-dependent Egr4 expression and rapid Egr4-dependent activation of the KCC2b promoter. The subsequent increase in KCC2b mRNA contributes to the expression of total KCC2 protein levels. 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These results indicate that Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Brain-Derived Neurotrophic Factor - biosynthesis</subject><subject>Brief Communications</subject><subject>Cells, Cultured</subject><subject>Early Growth Response Transcription Factors - physiology</subject><subject>Hippocampus - metabolism</subject><subject>K Cl- Cotransporters</subject><subject>Mice</subject><subject>Mitogen-Activated Protein Kinase 1 - physiology</subject><subject>Mitogen-Activated Protein Kinase 3 - physiology</subject><subject>Neurons - metabolism</subject><subject>Promoter Regions, Genetic</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Signal Transduction</subject><subject>Symporters - biosynthesis</subject><subject>Symporters - genetics</subject><subject>Transcription, Genetic</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctP9CAUxYnR6Pj4Fww7V9ULpdDZfMnnOL5iNPGxJhSog-mUCq3G_17qY6IrV-Tee87JIT-E9gkckoLmR5fX84fbm7vZxSEF4FlaUyBkDU3SdZpRBmQdTYAKyDgTbAttx_gEAAKI2ERblFBaEpFPkJ6r0Lzhx-Bf-wUONna-jRYzvLTGqd5GfHxyfYpdawbdO99iX-PO9ypGNyyxXjQ-OGOx9n1QbTKH3gZM8cekg-tGzy7aqFUT7d7Xu4MeTuf3s_Ps6ubsYvb_KtMFZ33GpopVhVaGaMKUSgPVRmll8xpIISpSmYpAWXIuwOja2IrVJmfArGKWCpbvoH-fud1QpfratqlGI7vgliq8Sa-c_H1p3UI--hfJOc1ZIVLAwVdA8M-Djb1cuqht06jW-iHKKYhUhEzpn8qSQc5KDiQp-adSBx9jsPWqDwE5opQrlHJEOa5HlMm4__M3K9s3u_wdu6ieow</recordid><startdate>20110112</startdate><enddate>20110112</enddate><creator>Ludwig, Anastasia</creator><creator>Uvarov, Pavel</creator><creator>Soni, Shetal</creator><creator>Thomas-Crusells, Judith</creator><creator>Airaksinen, Matti S</creator><creator>Rivera, Claudio</creator><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110112</creationdate><title>Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription</title><author>Ludwig, Anastasia ; Uvarov, Pavel ; Soni, Shetal ; Thomas-Crusells, Judith ; Airaksinen, Matti S ; Rivera, Claudio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-49a4b5cad1c14aaa4b2cdacae3f0157b1bdb10886670dcfdeb4fd3404ea4e2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Brain-Derived Neurotrophic Factor - biosynthesis</topic><topic>Brief Communications</topic><topic>Cells, Cultured</topic><topic>Early Growth Response Transcription Factors - physiology</topic><topic>Hippocampus - metabolism</topic><topic>K Cl- Cotransporters</topic><topic>Mice</topic><topic>Mitogen-Activated Protein Kinase 1 - physiology</topic><topic>Mitogen-Activated Protein Kinase 3 - physiology</topic><topic>Neurons - metabolism</topic><topic>Promoter Regions, Genetic</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Signal Transduction</topic><topic>Symporters - biosynthesis</topic><topic>Symporters - genetics</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ludwig, Anastasia</creatorcontrib><creatorcontrib>Uvarov, Pavel</creatorcontrib><creatorcontrib>Soni, Shetal</creatorcontrib><creatorcontrib>Thomas-Crusells, Judith</creatorcontrib><creatorcontrib>Airaksinen, Matti S</creatorcontrib><creatorcontrib>Rivera, Claudio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ludwig, Anastasia</au><au>Uvarov, Pavel</au><au>Soni, Shetal</au><au>Thomas-Crusells, Judith</au><au>Airaksinen, Matti S</au><au>Rivera, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2011-01-12</date><risdate>2011</risdate><volume>31</volume><issue>2</issue><spage>644</spage><epage>649</epage><pages>644-649</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>A major event in the maturation of CNS GABAergic transmission is the qualitative change in GABA(A)-mediated responses from depolarizing to hyperpolarizing. In cortical regions, this is attributed to the increased expression of potassium chloride cotransporter 2b (KCC2b), the main isoform of the neuron-specific K-Cl cotransporter KCC2. We have previously shown that transcription factor early growth response 4 (Egr4) can activate the KCC2b promoter. Here we demonstrate that in immature hippocampal neurons BDNF robustly induces ERK1/2 (extracellular signal-regulated kinase 1/2)-dependent Egr4 expression and rapid Egr4-dependent activation of the KCC2b promoter. The subsequent increase in KCC2b mRNA contributes to the expression of total KCC2 protein levels. These results indicate that Egr4 is an important component in the mechanism of BDNF-dependent KCC2 gene regulation via the ERK1/2 pathway in immature neurons.</abstract><cop>United States</cop><pub>Society for Neuroscience</pub><pmid>21228173</pmid><doi>10.1523/JNEUROSCI.2006-10.2011</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Binding Sites Brain-Derived Neurotrophic Factor - biosynthesis Brief Communications Cells, Cultured Early Growth Response Transcription Factors - physiology Hippocampus - metabolism K Cl- Cotransporters Mice Mitogen-Activated Protein Kinase 1 - physiology Mitogen-Activated Protein Kinase 3 - physiology Neurons - metabolism Promoter Regions, Genetic RNA, Messenger - biosynthesis Signal Transduction Symporters - biosynthesis Symporters - genetics Transcription, Genetic |
| title | Early growth response 4 mediates BDNF induction of potassium chloride cotransporter 2 transcription |
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