Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors

The neuronal α4β2 nicotinic acetylcholine receptors exist as two distinct subtypes, (α4)(2)(β2)(3) and (α4)(3)(β2)(2), and biphasic responses to acetylcholine and other agonists have been ascribed previously to coexistence of these two receptor subtypes. We offer a novel and radical explanation for...

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Veröffentlicht in:	The Journal of neuroscience 2011-07, Vol.31 (30), p.10759-10766
Hauptverfasser:	Harpsøe, Kasper, Ahring, Philip K, Christensen, Jeppe K, Jensen, Marianne L, Peters, Dan, Balle, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Azepines - pharmacology Binding Sites - drug effects Binding Sites - genetics Cholinergic Agonists - pharmacology Dose-Response Relationship, Drug Larva Membrane Potentials - drug effects Membrane Potentials - genetics Models, Molecular Mutagenesis, Site-Directed - methods Oocytes Protein Binding - drug effects Protein Subunits - genetics Pyridines - pharmacology Receptors, Nicotinic - classification Receptors, Nicotinic - genetics Sensitivity and Specificity Sequence Alignment Transfection - methods
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