Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus

Activation of Group I metabotropic glutamate receptors (mGluRs) in rat hippocampus induces a form of long-term depression (LTD) that is dependent on protein synthesis. However, the intracellular mechanisms leading to the initiation of protein synthesis and expression of LTD after mGluR activation ar...

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Veröffentlicht in:	The Journal of neuroscience 2011-05, Vol.31 (20), p.7380-7391
Hauptverfasser:	Mockett, Bruce G, Guévremont, Diane, Wutte, Magdalena, Hulme, Sarah R, Williams, Joanna M, Abraham, Wickliffe C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Hippocampus - drug effects Hippocampus - enzymology Long-Term Synaptic Depression - drug effects Long-Term Synaptic Depression - physiology Male Methoxyhydroxyphenylglycol - analogs & derivatives Methoxyhydroxyphenylglycol - pharmacology Organ Culture Techniques Protein Biosynthesis - drug effects Protein Biosynthesis - physiology Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - physiology
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