The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss

Extensive evidence supports a central role for amyloid-β (Aβ) in the pathogenesis of Alzheimer's disease (AD). Synaptic loss mediated by Aβ in early stages of the disease might contribute to cognitive impairments. However, little is known about the mechanism by which Aβ induces the loss of syna...

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Veröffentlicht in:	The Journal of neuroscience 2012-03, Vol.32 (10), p.3492-3498
Hauptverfasser:	Purro, Silvia A, Dickins, Ellen M, Salinas, Patricia C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - toxicity Animals Brief Communications Female Hippocampus - metabolism Hippocampus - pathology Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - physiology Male Mice Rats Synapses - metabolism Synapses - pathology Up-Regulation - physiology Wnt Signaling Pathway - physiology
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