Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa -induced sepsis pig model

Maintenance of gut integrity has long been recognized as crucial for survival in sepsis, but alterations in protein metabolism have not previously been documented. Therefore, in the present study, we measured in a -induced porcine sepsis model fractional protein synthesis (FSR) and breakdown rates (...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2019-06, Vol.316 (6), p.G755-G762
Hauptverfasser:	Ten Have, Gabriëlla A M, Engelen, Mariëlle P K J, Wolfe, Robert R, Deutz, Nicolaas E P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Consciousness Disease Models, Animal Ileum Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Jejunum Jejunum - metabolism Jejunum - pathology Liver Liver - metabolism Liver - pathology Metabolism Mucosa Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Phenylalanine Phenylalanine - pharmacokinetics Protein Biosynthesis Protein synthesis Protein turnover Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - physiology Radioactive Tracers Sepsis Sepsis - metabolism Sepsis - microbiology Swine
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