Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium

Liver X receptors (LXRs) are ligand-dependent transcription factors activated by cholesterol metabolites. These receptors induce a suite of target genes required for de novo synthesis of triglycerides and cholesterol transport in many tissues. Two different isoforms, LXRα and LXRβ, have been well ch...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2019-06, Vol.316 (6), p.E1136-E1145
Hauptverfasser:	Grinman, Diego Y, Careaga, Valeria P, Wellberg, Elizabeth A, Dansey, María V, Kordon, Edith C, Anderson, Steven M, Maier, Marta S, Burton, Gerardo, MacLean, Paul S, Rudolph, Michael C, Pecci, Adali
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adipocytes Animals ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Benzoates - pharmacology Benzylamines - pharmacology Breastfeeding & lactation Cell Line Cholesterol Cholesterol - metabolism Efflux Epithelial cells Epithelium Epithelium - metabolism Fatty acids Female Gene Expression Regulation Genes Intestine Isoforms Lactation Lactation - genetics Lactation - metabolism Lipids Lipogenesis Lipogenesis - genetics Liver Liver X receptors Liver X Receptors - genetics Liver X Receptors - metabolism Macrophages Mammary gland Mammary Glands, Animal - metabolism Metabolites Mice Milk Milk - metabolism Pharmacology Proteins Receptors Retinoid X receptors RNA, Messenger - metabolism Secretion Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterol regulatory element-binding protein Sterol regulatory element-binding protein 1c Therapeutic applications Transcription factors Transport Triglycerides
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