Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release

At the nerve terminal, neurotransmitter release is triggered by Ca(2+) influx through voltage-gated Ca(2+) channels (VGCCs). During postnatal development, VGCC subtypes in the nerve terminal switch at many synapses. In immature rodent cerebella, N-type and P/Q-type VGCCs mediate GABAergic neurotrans...

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Veröffentlicht in:	The Journal of neuroscience 2013-11, Vol.33 (48), p.18755-18763
Hauptverfasser:	Miki, Takafumi, Hirai, Hirokazu, Takahashi, Tomoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - pharmacology Animals Brain-Derived Neurotrophic Factor - metabolism Calcium Channels - drug effects Calcium Channels - physiology Calcium Channels, N-Type - physiology Calcium Channels, P-Type - physiology Calcium Channels, Q-Type - physiology Cerebellum - drug effects Cerebellum - physiology Electrophysiological Phenomena - physiology Female Genetic Vectors Immunohistochemistry In Vitro Techniques Lentivirus - genetics Male Nerve Endings - drug effects Nerve Endings - metabolism Nerve Endings - physiology Nerve Growth Factors - physiology Neurotransmitter Agents - metabolism Presynaptic Terminals - physiology Rats Rats, Wistar Receptor, trkB - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tetrodotoxin - pharmacology
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