Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons

Thrombospondin-1 (TSP-1) is a large extracellular matrix protein secreted by astrocytes during development and inflammation. In the developing CNS, TSP-1 is involved in neuronal migration and adhesion, neurite outgrowth, and synaptogenesis. We investigated the effects of TSP-1 on neurons with mature...

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Veröffentlicht in:	The Journal of neuroscience 2013-07, Vol.33 (28), p.11432-11439
Hauptverfasser:	Hennekinne, Laetitia, Colasse, Sabrina, Triller, Antoine, Renner, Marianne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Female Male Neurons - drug effects Neurons - metabolism Rats Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, Glycine - agonists Receptors, Glycine - metabolism Spinal Cord - drug effects Spinal Cord - metabolism Synapses - drug effects Synapses - metabolism Thrombospondin 1 - physiology
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