Loss of Otx2 in the adult retina disrupts retinal pigment epithelium function, causing photoreceptor degeneration

Photoreceptors are specialized neurons of the retina that receive nursing from the adjacent retinal pigment epithelium (RPE). Frequent in the elderly, photoreceptor loss can originate from primary dysfunction of either cell type. Despite intense interest in the etiology of these diseases, early mole...

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Veröffentlicht in:	The Journal of neuroscience 2013-06, Vol.33 (24), p.9890-9904
Hauptverfasser:	Housset, Michael, Samuel, Alexander, Ettaiche, Mohamed, Bemelmans, Alexis, Béby, Francis, Billon, Nathalie, Lamonerie, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Astrocytes - physiology Chromatin Immunoprecipitation Development Biology Disease Models, Animal Electroretinography Female Gene Expression Profiling Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Genetic Vectors - physiology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Lentivirus - genetics Life Sciences Male Mice Mice, Transgenic Models, Biological Oligonucleotide Array Sequence Analysis Otx Transcription Factors - deficiency Otx Transcription Factors - genetics Photoreceptor Cells - metabolism Photoreceptor Cells - pathology Protein Binding - drug effects Protein Binding - genetics Retina - pathology Retinal Degeneration - genetics Retinal Degeneration - pathology Retinal Pigment Epithelium - pathology Retinal Pigment Epithelium - physiopathology RNA, Messenger
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