Multi-omic molecular profiling of lung cancer in COPD

Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer but the underlying mechanisms remain unknown. We hypothesise that the COPD stroma contains molecular mechanisms supporting tumourigenesis.We conducted an unbiased multi-omic analysis to identify gene expre...

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Veröffentlicht in:	The European respiratory journal 2018-07, Vol.52 (1), p.1702665-1702665
Hauptverfasser:	Sandri, Brian J, Kaplan, Adam, Hodgson, Shane W, Peterson, Mark, Avdulov, Svetlana, Higgins, LeeAnn, Markowski, Todd, Yang, Ping, Limper, Andrew H, Griffin, Timothy J, Bitterman, Peter, Lock, Eric F, Wendt, Chris H
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Chronic obstructive pulmonary disease Extracellular matrix Gene expression Kinases Lung cancer Lung diseases Molecular modelling Obstructive lung disease Phosphatidylinositol 4,5-diphosphate Proteomics Signal transduction Stroma Tumorigenesis Tumors
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