IL‐2 therapy preferentially expands adoptively transferred donor‐specific Tregs improving skin allograft survival

Regulatory T cells (Tregs) have unique immunosuppressive properties and are essential to ensure effective immunoregulation. In animal models, Tregs have been shown to prevent autoimmune disorders and establish transplantation tolerance. Therefore, the prospect of harnessing Tregs, either by increasi...

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Veröffentlicht in:	American journal of transplantation 2019-07, Vol.19 (7), p.2092-2100
Hauptverfasser:	Ratnasothy, Kulachelvy, Jacob, Jacintha, Tung, Sim, Boardman, Dominic, Lechler, Robert Ian, Sanchez-Fueyo, Alberto, Martinez‐Llordella, Marc, Lombardi, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Allografts Animal models Animals antigen presentation/recognition Autoimmune diseases basic (laboratory) research/science Brief Communication Brief Communications CTLA-4 protein Drug Synergism Graft Survival Histocompatibility - immunology immune regulation immunobiology Immunological tolerance Immunoregulation immunosuppression/immune modulation Immunotherapy Interleukin-2 - administration & dosage Lymph nodes Lymphocytes T Major histocompatibility complex Mice Mice, Inbred CBA Mice, Transgenic organ transplantation in general Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Skin Skin Transplantation - methods T cell biology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - transplantation Tissue Donors tolerance translational research/science Transplantation Transplantation Tolerance - immunology Transplantation, Homologous Transplants & implants
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